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Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. Isotetrandrine has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. Isotetrandrine has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTPβS and Ca2+. Isotetrandrine is an inhibitor of AR (α1 adrenoceptor).
1. Hashizume, T., et al. 1991. Biochem. Pharmacol. 41: 419-423. PMID: 1899790
2. Akiba, S., et al. 1992. Biochem. Pharmacol. 44: 45-50. PMID: 1632837
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