Molecular structure of Isotetrandrine, CAS Number: 477-57-6
Isotetrandrine (CAS 477-57-6)
See product citations (2)
Alternate Names:
Berbamine methyl ether
Application:
Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2
CAS Number:
477-57-6
Purity:
98%
Molecular Weight:
622.80
Molecular Formula:
C38H42N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. Isotetrandrine has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. Isotetrandrine has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTPbetaS and Ca2+. Isotetrandrine is an inhibitor of AR (alpha1 adrenoceptor).
Isotetrandrine (CAS 477-57-6) References
- Tetrandrine and isotetrandrine, two bisbenzyltetrahydroisoquinoline alkaloids from Menispermaceae, with rat uterine smooth muscle relaxant activity. | D'Ocón, P., et al. 1992. J Pharm Pharmacol. 44: 579-82. PMID: 1357138
- In-vitro metabolism of isotetrandrine, a bisbenzylisoquinoline alkaloid, in rat hepatic S9 fraction by high-performance liquid chromatography-atmospheric pressure ionization mass spectrometry. | Wu, WN., et al. 2004. J Pharm Pharmacol. 56: 749-55. PMID: 15231040
- Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells. | Akiba, S., et al. 1992. Biochem Pharmacol. 44: 45-50. PMID: 1632837
- Reversal effect of isotetrandrine, an isoquinoline alkaloid extracted from Caulis Mahoniae, on P-glycoprotein-mediated doxorubicin-resistance in human breast cancer (MCF-7/DOX) cells. | Wang, TX. and Yang, XH. 2008. Yao Xue Xue Bao. 43: 461-6. PMID: 18717331
- Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets. | Hashizume, T., et al. 1991. Biochem Pharmacol. 41: 419-23. PMID: 1899790
- Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B. | Liang, XM., et al. 2014. J Surg Res. 187: 596-604. PMID: 24331940
- Isotetrandrine Reduces Astrocyte Cytotoxicity in Neuromyelitis Optica by Blocking the Binding of NMO-IgG to Aquaporin 4. | Sun, M., et al. 2016. Neuroimmunomodulation. 23: 98-108. PMID: 27064690
- Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression. | Wang, L., et al. 2016. Exp Biol Med (Maywood). 241: 1568-76. PMID: 27190261
- A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine. | Schütz, R., et al. 2020. Org Biomol Chem. 18: 3047-3068. PMID: 32091528
- Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB. | Xu, W., et al. 2021. Z Naturforsch C J Biosci. 76: 21-25. PMID: 33119545
- Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages. | Song, MY., et al. 2022. Acta Pharmacol Sin. 43: 1274-1284. PMID: 34417574
- Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine. | Inubushi, Y., et al. 1968. Tetrahedron Lett. 3399-402. PMID: 5653568
- Alpha-adrenoceptor interaction of tetrandrine and isotetrandrine in the rat: functional and binding assays. | Catret, M., et al. 1998. J Pharm Pharmacol. 50: 1267-73. PMID: 9877313
Inhibitor of:
AR, and P5CRL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isotetrandrine, 1 mg | sc-200869 | 1 mg | $124.00 | |||
Isotetrandrine, 5 mg | sc-200869A | 5 mg | $344.00 |