Isosilybin A (CAS 142796-21-2)
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Isosilybin A is a flavonolignan and one of the components available in silymarin, which is isolated from the milk thistle plant (Silybum marianum). It has hepatoprotective, antioxidant, anti-cancer, and anti-inflammatory properties. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin A inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. Isosilybin A reduces tumor volume and increases tumor cell apoptosis. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Isosilybin A (CAS 142796-21-2) References
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- Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. | Deep, G., et al. 2010. Mol Carcinog. 49: 902-12. PMID: 20721970
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isosilybin A, 5 mg | sc-506052 | 5 mg | $750.00 |