Molecular structure of Isorhamnetin, CAS Number: 480-19-3
Isorhamnetin (CAS 480-19-3)
See product citations (6)
Alternate Names:
3-Methylquercetin; Quercetin-3′-methyl ether
Application:
Isorhamnetin is an antiviral, antioxidant apoptosis inducer
CAS Number:
480-19-3
Purity:
≥98%
Molecular Weight:
316.26
Molecular Formula:
C16H12O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isorhamnetin acts as an antioxidant, an antitumor compound, and an apoptosis inducer. Isorhamnetin is a flavonoid compound, a type of plant secondary metabolite. In plant biochemistry, isorhamnetin plays a significant role in the defense mechanisms of plants against environmental stresses, such as UV radiation, pathogens, and herbivores. It contributes to the coloration of flowers and fruits, attracting pollinators and aiding in seed dispersal. The study of isorhamnetin and related flavonoids helps elucidate the complex interactions between plants and their environments, offering insights into the evolution of plant defense strategies and the ecological balance within various ecosystems.
Isorhamnetin (CAS 480-19-3) References
- Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. | Ito, H., et al. 1999. Cancer Lett. 143: 5-13. PMID: 10465331
- Inhibition of xanthine oxidase by flavonoids. | Nagao, A., et al. 1999. Biosci Biotechnol Biochem. 63: 1787-90. PMID: 10671036
- Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | Zou, L., et al. 2002. Phytomedicine. 9: 263-7. PMID: 12046870
- Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. | Yokozawa, T., et al. 2002. J Agric Food Chem. 50: 5490-5. PMID: 12207497
- Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. | Chen, G., et al. 2002. Clin Chim Acta. 326: 169-75. PMID: 12417109
- Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | Bao, M. and Lou, Y. 2006. Eur J Pharmacol. 547: 22-30. PMID: 16963021
- The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. | Ma, G., et al. 2007. Chem Biol Interact. 167: 153-60. PMID: 17368593
- ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine. | Hu, J., et al. 2019. J Exp Clin Cancer Res. 38: 225. PMID: 31138329
- Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways. | Liu, N., et al. 2019. Mediators Inflamm. 2019: 6175091. PMID: 31467486
- Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice. | Lee, HK., et al. 2021. Int J Mol Sci. 22: PMID: 33921231
- Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation. | Rodríguez, L., et al. 2021. Antioxidants (Basel). 10: PMID: 33922903
- Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway. | Wu, Y., et al. 2021. Inflammation. 44: 1993-2005. PMID: 33999329
- Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2. | Rousta, AM., et al. 2022. Drug Res (Stuttg). 72: 245-254. PMID: 35359022
- Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD. | Xu, Y., et al. 2022. Front Pharmacol. 13: 860362. PMID: 35401244
- Isorhamnetin inhibits progression of ovarian cancer by targeting ESR1. | Wang, M., et al. 2022. Ann Transl Med. 10: 1216. PMID: 36544694
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isorhamnetin, 5 mg | sc-202668 | 5 mg | $204.00 | |||
Isorhamnetin, 10 mg | sc-202668A | 10 mg | $281.00 | |||
Isorhamnetin, 25 mg | sc-202668B | 25 mg | $510.00 |