Molecular structure of Isoquinoline-5-sulfonyl Chloride, Hydrochloride, CAS Number: 105627-79-0
Isoquinoline-5-sulfonyl Chloride, Hydrochloride (CAS 105627-79-0)
Application:
Isoquinoline-5-sulfonyl Chloride, Hydrochloride is Useful in the synthesis of PKA inhibitors
CAS Number:
105627-79-0
Molecular Weight:
264.13
Molecular Formula:
C9H6ClNO2S HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isoquinoline-5-sulfonyl Chloride, Hydrochloride is an Isoquinoline sulfonamide, which is shown to act as an inhibitor of mammalian protein kinases by competitively binding to ATP. Studies indicate that Isoquinoline-5-sulfonyl Chloride, Hydrochloride can be used to produce PKA inhibitors.
Isoquinoline-5-sulfonyl Chloride, Hydrochloride (CAS 105627-79-0) References
- Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. | Collins, I., et al. 2006. Bioorg Med Chem. 14: 1255-73. PMID: 16249095
- Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide. | Vasdev, N., et al. 2008. Bioorg Med Chem. 16: 5277-84. PMID: 18346896
- Design of potent protein kinase inhibitors using the bisubstrate approach. | Ricouart, A., et al. 1991. J Med Chem. 34: 73-8. PMID: 1992155
- Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors. | van Wandelen, LT., et al. 2012. ChemMedChem. 7: 2113-21. PMID: 23139239
- Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor. | Jin, F., et al. 2013. Bioorg Med Chem. 21: 5694-706. PMID: 23932071
- Identification and characterization of the process-related impurities in fasudil hydrochloride by hyphenated techniques using a quality by design approach. | Song, M., et al. 2014. J Sep Sci. 37: 758-63. PMID: 24470347
- Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. | Park, JH., et al. 2015. J Med Chem. 58: 2114-34. PMID: 25597334
- Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. | Gerard, C., et al. 1986. J Clin Invest. 77: 61-5. PMID: 3003155
- Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. | Singh, V., et al. 2019. Eur J Med Chem. 174: 309-329. PMID: 31055147
- Rapid Synthesis of 3-Aminoisoquinoline-5-sulfonamides Using the Buchwald-Hartwig Reaction | Proisy, N., Taylor, S., Nelson, A., & Collins, I. 2009. Synthesis. 2009(04): 561-566.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoquinoline-5-sulfonyl Chloride, Hydrochloride, 1 g | sc-207773 | 1 g | $360.00 |