isoquinoline-1,3(2H,4H)-dione (CAS 4456-77-3)
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isoquinoline-1,3(2H,4H)-dione is a compound that functions as an inhibitor of certain enzymes involved in cellular processes. It binds to the active site of the enzyme, preventing its normal substrate from binding and inhibiting the enzyme′s activity. Isoquinoline-1,3(2H,4H)-dione targets enzymes involved in key metabolic pathways, disrupting their function and leading to downstream effects on cellular processes. By interfering with the activity of these enzymes, isoquinoline-1,3(2H,4H)-dione can be used to study the specific roles of these enzymes in cellular function and metabolism. isoquinoline-1,3(2H,4H)-dione provides insights into the biochemical pathways and processes in which these enzymes are involved, contributing to a better understanding of cellular function and potential targets.
isoquinoline-1,3(2H,4H)-dione (CAS 4456-77-3) References
- Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. | Tsou, HR., et al. 2009. J Med Chem. 52: 2289-310. PMID: 19317452
- Molecular-docking-guided 3D-QSAR studies of substituted isoquinoline-1,3-(2H,4H)-diones as cyclin-dependent kinase 4 (CDK4) inhibitors. | Lu, XY., et al. 2010. J Mol Model. 16: 163-73. PMID: 19543928
- Insight into the interactions between novel isoquinolin-1,3-dione derivatives and cyclin-dependent kinase 4 combining QSAR and molecular docking. | Zheng, J., et al. 2014. PLoS One. 9: e93704. PMID: 24722522
- Cascade couplings of N-alkyl-N-methacryloyl benzamides with ethers and benzenesulfonohydrazides to generate isoquinoline-1,3(2H,4H)-dione derivatives. | Zhang, M., et al. 2015. J Org Chem. 80: 4176-83. PMID: 25785787
- Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2). | Kankanala, J., et al. 2016. J Med Chem. 59: 2734-46. PMID: 26910725
- Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2 H,4 H)-diones. | Yang, Y., et al. 2018. J Org Chem. 83: 3348-3353. PMID: 29400968
- Design, synthesis, and biological evaluation of a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon modulators. | Liu, Y., et al. 2022. J Enzyme Inhib Med Chem. 37: 1715-1723. PMID: 35698881
- Recent developments in the synthesis of the isoquinoline-1,3(2H,4H)-dione by radical cascade reaction. | Niu, YN. and Xia, XF. 2022. Org Biomol Chem. 20: 7861-7885. PMID: 36185038
- New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction | Ding Yuan, Zhuan Duan, Yong Rao, Ming-Wu Ding. 2016. 72: 338-346.
- Direct C(sp3)−H Sulfonylation and Sulfuration Reactions of Isoquinoline-1,3(2H,4H)-diones under Metal-free Conditions | Xing-Lan Wang, Xue Bai, Chun-Feng Wu, Yong-Xi Dong, Min Zhang, Ling-Ling Fan, Lei Tang, Yuan-Yong Yang, Ji-Quan Zhang. 2021. Asian Journal of Organic Chemistry. 10: 386-391.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
isoquinoline-1,3(2H,4H)-dione, 1 g | sc-279244 | 1 g | $296.00 |