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Isopropyl p-toluenesulfonate (CAS 2307-69-9)

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Alternate Names:
Isopropyl 4-methylbenzenesulfonate
Application:
Isopropyl p-toluenesulfonate is A sulfur compound for proteomics research
CAS Number:
2307-69-9
Purity:
≥95%
Molecular Weight:
214.28
Molecular Formula:
C10H14O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isopropyl p-toluenesulfonate is a highly versatile molecule extensively employed in chemistry and biochemistry for various applications. It finds wide utilization in research, particularly in organic synthesis, catalysis, and biochemistry. As a catalyst, it plays a role in organic compound synthesis, enabling the creation of carbon-carbon bonds. Moreover, its significance extends to the synthesis of polymers, surfactants, and diverse materials. In the realm of biochemistry, Isopropyl p-toluenesulfonate serves as both a substrate for enzymes and a reagent for biochemical assays.


Isopropyl p-toluenesulfonate (CAS 2307-69-9) References

  1. Determination of the carbon kinetic isotope effects on propane hydroxylation mediated by the methane monooxygenases from Methylococcus capsulatus (Bath) by using stable carbon isotopic analysis.  |  Huang, DS., et al. 2002. Chembiochem. 3: 760-5. PMID: 12203974
  2. Solvolysis-decomposition of 2-adamantyl chloroformate: evidence for two reaction pathways.  |  Kyong, JB., et al. 2003. J Org Chem. 68: 3425-32. PMID: 12713342
  3. A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization-headspace-gas chromatography-mass spectrometry.  |  Alzaga, R., et al. 2007. J Pharm Biomed Anal. 45: 472-9. PMID: 17719195
  4. Control and analysis of alkyl esters of alkyl and aryl sulfonic acids in novel active pharmaceutical ingredients (APIs).  |  Elder, DP., et al. 2008. J Pharm Biomed Anal. 46: 1-8. PMID: 18053672
  5. A practical derivatization LC/MS approach for determination of trace level alkyl sulfonates and dialkyl sulfates genotoxic impurities in drug substances.  |  An, J., et al. 2008. J Pharm Biomed Anal. 48: 1006-10. PMID: 18687555
  6. HILIC methods in pharmaceutical analysis.  |  Dejaegher, B. and Vander Heyden, Y. 2010. J Sep Sci. 33: 698-715. PMID: 20183826
  7. Rapid and simultaneous determination of sulfonate ester genotoxic impurities in drug substance by liquid chromatography coupled to tandem mass spectrometry: comparison of different ionization modes.  |  Guo, T., et al. 2014. J Chromatogr A. 1355: 73-9. PMID: 24997109
  8. Determination and confirmation of isopropyl p-toluenesulfonate in cosmetics by HPLC-diode array detector method and GC-MS.  |  Tay, BY., et al. 2016. Int J Cosmet Sci. 38: 627-633. PMID: 27169828
  9. The rat Pig-a assay using an erythroid HIS49 antibody in a single dose study of isopropyl p-toluenesulfonate.  |  Chikura, S., et al. 2016. Mutat Res Genet Toxicol Environ Mutagen. 811: 110-116. PMID: 27931803
  10. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.  |  Kimoto, T., et al. 2016. Mutat Res Genet Toxicol Environ Mutagen. 811: 3-15. PMID: 27931811
  11. Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept.  |  Zacharis, CK. and Vastardi, E. 2018. J Pharm Biomed Anal. 150: 152-161. PMID: 29245084
  12. Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS.  |  Jin, B., et al. 2019. J Anal Methods Chem. 2019: 4059765. PMID: 31687249

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isopropyl p-toluenesulfonate, 5 g

sc-263414
5 g
$92.00

Isopropyl p-toluenesulfonate, 25 g

sc-263414A
25 g
$163.00

Isopropyl p-toluenesulfonate, 100 g

sc-263414B
100 g
$587.00

what is the boiling point and gas chromatograph method of analysis of this compound

Asked by: malli
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which may include if certain tests were performed. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about a sample CoA of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26

I would like to know what is the odour/smell of Isopropyl p-toluenesulfonate (CAS 2307-69-9).

Asked by: Yen Yen
Thank you for your question. Odor has not been reported for this chemical.
Answered by: Technical Support
Date published: 2017-07-19
  • y_2025, m_10, d_14, h_6CST
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Rated 5 out of 5 by from Various publications cite the use of Isopropyl pVarious publications cite the use of Isopropyl p-toluenesulfonate in proteomics research. -SCBT Publication Review
Date published: 2015-04-20
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Isopropyl p-toluenesulfonate is rated 5.0 out of 5 by 1.
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