Date published: 2026-5-22

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Isopregnanolone (CAS 516-55-2)

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Alternate Names:
(3β,5α)-3-Hydroxy-pregnan-20-one
CAS Number:
516-55-2
Molecular Weight:
318.49
Molecular Formula:
C21H34O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isopregnanolone is a occurring neurosteroid that is derived from the progesterone hormone. It is produced in the central nervous system and acts as a positive allosteric modulator of the GABAA receptor, which is the main inhibitory neurotransmitter receptor in the brain. Its ability to enhance GABAA receptor function makes it an important molecule in neurobiology and pharmacology. Isopregnanolone is involved in the modulation of stress response and has been studied for its potential role in the regulation of mood and behavior. Its interaction with the GABAA receptor makes it an intriguing target for further study in the field of neuroscience.


Isopregnanolone (CAS 516-55-2) References

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  2. Neuroactive pregnanolone isomers during pregnancy.  |  Parízek, A., et al. 2005. J Clin Endocrinol Metab. 90: 395-403. PMID: 15486056
  3. Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.  |  Hill, M., et al. 2005. Steroids. 70: 515-24. PMID: 15894035
  4. Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol.  |  Debatin, T. and Barbosa, AD. 2006. Braz J Psychiatry. 28: 18-23. PMID: 16612485
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  6. Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy.  |  Caruso, D., et al. 2008. J Mol Neurosci. 34: 249-53. PMID: 18193358
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  9. Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis.  |  Caruso, D., et al. 2010. J Neurochem. 114: 921-32. PMID: 20492360
  10. Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease.  |  Melcangi, RC., et al. 2012. J Mol Neurosci. 46: 177-83. PMID: 21671084
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  14. Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns.  |  McCallie, KR., et al. 2017. J Perinatol. 37: 591-595. PMID: 28102853
  15. The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.  |  Chen, SW., et al. 1996. Pharmacol Biochem Behav. 53: 777-82. PMID: 8801578

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isopregnanolone, 100 mg

sc-489301
100 mg
$317.00