Molecular structure of Isopimaric Acid, CAS Number: 5835-26-7
Isopimaric Acid (CAS 5835-26-7)
See product citations (2)
Alternate Names:
13-Methyl-17-norabieta-7,15-diene-18-oic acid
Application:
Isopimaric Acid is potent Ca-activated K+ channel opener
CAS Number:
5835-26-7
Molecular Weight:
302.45
Molecular Formula:
C20H30O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Isopimaric Acid is a naturally occurring fatty acid found in the seed oils of various plants and trees, including pines and spruces. It is a major component of the resin of certain species of conifers and is also found in the waxes of certain species of flowering plants. It potently opens large conductance Ca-activated K+ channels. Isopimaric Acid acts as an antioxidant and anti-inflammatory agent. It has also been shown to modulate gene expression and to have anti-cancer activity. In addiction, it is an important component of several industrial products, including lubricants, antifoams, and surfactants.
Isopimaric Acid (CAS 5835-26-7) References
- Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. | Imaizumi, Y., et al. 2002. Mol Pharmacol. 62: 836-46. PMID: 12237330
- Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus. | Smith, E., et al. 2005. Phytother Res. 19: 538-42. PMID: 16114093
- Stimulation of Ca2+-gated Cl- currents by the calcium-dependent K+ channel modulators NS1619 [1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and isopimaric acid. | Saleh, SN., et al. 2007. J Pharmacol Exp Ther. 321: 1075-84. PMID: 17347326
- Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids. | Janocha, S., et al. 2013. Chembiochem. 14: 467-73. PMID: 23371760
- Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme. | Gnanasekaran, T., et al. 2015. J Biol Eng. 9: 24. PMID: 26702299
- Crystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound Form. | Janocha, S., et al. 2016. Chembiochem. 17: 852-60. PMID: 26864272
- Secondary metabolites isolated from Pinus roxburghii and interpretation of their cannabinoid and opioid binding properties by virtual screening and in vitro studies. | Labib, RM., et al. 2018. Saudi Pharm J. 26: 437-444. PMID: 29556136
- Functions of mountain pine beetle cytochromes P450 CYP6DJ1, CYP6BW1 and CYP6BW3 in the oxidation of pine monoterpenes and diterpene resin acids. | Chiu, CC., et al. 2019. PLoS One. 14: e0216753. PMID: 31071168
- Rubellawus A-D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti-NLRP3 Inflammasome Effects. | Wu, XW., et al. 2020. Chem Biodivers. 17: e2000798. PMID: 33135326
- The LC-MS/MS-Based Measurement of Isopimaric Acid in Rat Plasma and Application of Pharmacokinetics. | Huang, D., et al. 2021. Biomed Res Int. 2021: 2310422. PMID: 34692827
- Ultra High-Performance Supercritical Fluid Chromatography for the Quantitation of Diterpene Resin Acids in Norway Spruce Samples. | Goels, T., et al. 2022. Front Pharmacol. 13: 906411. PMID: 35770082
- Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis. | Li, J., et al. 2023. Toxicol Appl Pharmacol. 462: 116415. PMID: 36754215
- Key secondary metabolite markers for Wuchang Daohuaxiang rice discrimination in China. | Zhao, L., et al. 2023. Food Res Int. 169: 112943. PMID: 37254367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isopimaric Acid, 5 mg | sc-269270 | 5 mg | $78.00 |