Molecular structure of Isopilocarpine Hydrochloride, CAS Number: 28958-85-2
Isopilocarpine Hydrochloride (CAS 28958-85-2)
Alternate Names:
(3R,4R)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone Hydrochloride
CAS Number:
28958-85-2
Molecular Weight:
244.72
Molecular Formula:
C11H16N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Isopilocarpine hydrochloride (IpHCl), a natural substance obtained from the plant Isopilocarpus frutescens of the Rutaceae family. It′s been demonstrated to have anti-inflammatory impacts through the inhibition of pro-inflammatory cytokines and chemokines. Also, it has shown anticancer properties by curtailing the growth and multiplication of cancer cells. Furthermore, Isopilocarpine hydrochloride exhibited antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria. The precise mechanism of action for Isopilocarpine hydrochloride remains a puzzle, but it′s thought to function via an array of pathways. It′s been shown to suppress the production of pro-inflammatory cytokines and chemokines, impede the growth and multiplication of cancer cells, and exhibit antibacterial activity by disrupting bacterial cell wall synthesis.
Isopilocarpine Hydrochloride (CAS 28958-85-2) References
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- Combination medical treatment for primary open angle glaucoma and ocular hypertension: a network meta-analysis. | Michelessi, M., et al. 2014. Cochrane Database Syst Rev. 2014: PMID: 25774087
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- Optimization of Ultrasound-Assisted Extraction of Bioactive Compounds from Acacia Seyal Gum Using Response Surface Methodology and Their Chemical Content Identification by Raman, FTIR, and GC-TOFMS. | Maher, T., et al. 2021. Antioxidants (Basel). 10: PMID: 34679747
- Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives. | Heinz, CS., et al. 2023. J Nat Prod. 86: 869-881. PMID: 37042802
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- Separation and analysis of pilocarpine, isopilocarpine, and pilocarpic acid by reverse phase liquid chromatography: collaborative study. | Van Ackeren, JL., et al. 1984. J Assoc Off Anal Chem. 67: 924-6. PMID: 6501156
- Determination of pilocarpine in aqueous humour by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. | Matsuura, K., et al. 1993. J Chromatogr. 621: 173-80. PMID: 8294539
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- Determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine by high-performance liquid chromatography with tandem mass spectrometric detection. | van de Merbel, NC., et al. 1998. J Chromatogr B Biomed Sci Appl. 708: 103-12. PMID: 9653952
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isopilocarpine Hydrochloride, 1 mg | sc-489297A | 1 mg | $260.00 | |||
Isopilocarpine Hydrochloride, 5 mg | sc-489297 | 5 mg | $440.00 | |||
Isopilocarpine Hydrochloride, 50 mg | sc-489297B | 50 mg | $3200.00 |