Molecular structure of Isoniazid-d4, CAS Number: 774596-24-6
Isoniazid-d4 (CAS 774596-24-6)
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Alternate Names:
4-(Pyridine-d4)carboxylic Acid Hydrazide; Isonicotinic Acid-d4 Hydrazide; 4-(Hydrazinocarbonyl)pyridine-d4
Application:
Isoniazid-d4 is an inhibitor and an inducer of various isoforms of CYP450
CAS Number:
774596-24-6
Molecular Weight:
141.16
Molecular Formula:
C6H3D4N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isoniazid-d4 is a labeled form of isoniazid that inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. This compound is both an inhibitor and inducer of various isoforms of cytochrome P450, a family of enzymes extensively involved in the metabolism of xenobiotics. CYP isoforms induced by this product include CYP2E1. Isoniazid reversibly inhibits CYP2C19 and CYP3A4 and inactivates CYP1A2 and CYP2A6. The deuterated form is useful in kinetic isotope effect studies and as an internal standard for NMR experiments.
Isoniazid-d4 (CAS 774596-24-6) References
- Determination of ribavirin in human serum using liquid chromatography tandem mass spectrometry. | van der Lijke, H., et al. 2012. Talanta. 88: 385-90. PMID: 22265514
- Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis. | Gerona, R., et al. 2016. PLoS One. 11: e0155887. PMID: 27191185
- Simultaneous quantification of isoniazid, rifampicin, ethambutol and pyrazinamide by liquid chromatography/tandem mass spectrometry. | Prahl, JB., et al. 2016. APMIS. 124: 1004-1015. PMID: 27546025
- Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation. | Vinnard, C., et al. 2017. Br J Clin Pharmacol. 83: 801-811. PMID: 27792837
- Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid. | Chirehwa, MT., et al. 2019. J Antimicrob Chemother. 74: 139-148. PMID: 30239829
- Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans. | van Wijk, RC., et al. 2020. Br J Pharmacol. 177: 5518-5533. PMID: 32860631
- Simultaneous determination of first-line anti-tuberculosis drugs and one metabolite of isoniazid by liquid chromatography/tandem mass spectrometry in patients with human immunodeficiency virus-tuberculosis coinfection. | Xing, Y., et al. 2021. Heliyon. 7: e07532. PMID: 34296020
- Short-course daily isoniazid and rifapentine for latent tuberculosis infection in people living with HIV who received coformulated bictegravir/emtricitabine/tenofovir alafenamide. | Liou, BH., et al. 2021. J Int AIDS Soc. 24: e25844. PMID: 34822220
- A high-throughput LC-MS/MS method for simultaneous determination of isoniazid, ethambutol and pyrazinamide in human plasma. | Pršo, K., et al. 2023. Rapid Commun Mass Spectrom. 37: e9425. PMID: 36329637
Inhibitor of:
CYP2C19, and CYP3A4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoniazid-d4, 1 mg | sc-218611 | 1 mg | $406.00 |