Molecular structure of Isometamidium Chloride Hydrochloride
Isometamidium Chloride Hydrochloride (CAS 6798-24-9)
Alternate Names:
Samorin; Trypamidium; Veridium
CAS Number:
6798-24-9
Molecular Weight:
532.47
Molecular Formula:
C28H27Cl2N7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Isometamidium Chloride Hydrochloride is a synthetic compound bearing structural resemblance to resveratrol, a naturally occurring compound found in red wine associated with several health advantages. Research indicates that Isometamidium Chloride Hydrochloride possesses potential anti-cancer properties, impeding the growth of cancer cells and prompting apoptosis. It has also demonstrated the ability to activate sirtuins, proteins pivotal in governing cellular processes encompassing metabolism and aging. Moreover, Isometamidium Chloride Hydrochloride may exert its effects through the modulation of various signaling pathways, such as the PI3K/Akt and MAPK pathways.
Isometamidium Chloride Hydrochloride (CAS 6798-24-9) References
- Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei. | Boibessot, I., et al. 2002. Acta Trop. 84: 219-28. PMID: 12443800
- Development and validation of an improved HPLC method for the control of potentially counterfeit isometamidium products. | Schad, GJ., et al. 2008. J Pharm Biomed Anal. 46: 45-51. PMID: 17931814
- Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium. | Igoli, JO., et al. 2015. Anal Bioanal Chem. 407: 1171-80. PMID: 25515013
- Animal trypanosomosis: making quality control of trypanocidal drugs possible. | Sutcliffe, OB., et al. 2014. Rev Sci Tech. 33: 813-30. PMID: 25812206
- Drug quality analysis through high performance liquid chromatography of isometamidium chloride hydrochloride and diminazene diaceturate purchased from official and unofficial sources in Northern Togo. | Tchamdja, E., et al. 2016. Prev Vet Med. 126: 151-8. PMID: 26907208
- Synthesis and evaluation of isometamidium-alginate nanoparticles on equine mononuclear and red blood cells. | Singh, S., et al. 2016. Int J Biol Macromol. 92: 788-794. PMID: 27471088
- Drug quality analysis of isometamidium chloride hydrochloride and diminazene diaceturate used for the treatment of African animal trypanosomosis in West Africa. | Bengaly, Z., et al. 2018. BMC Vet Res. 14: 361. PMID: 30458767
- Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model. | Aregawi, WG., et al. 2021. J Parasit Dis. 45: 131-136. PMID: 33746398
- Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type. | Leschnik, M., et al. 2021. Tierarztl Prax Ausg K Kleintiere Heimtiere. 49: 142-147. PMID: 33902123
- Follow-up of dairy cattle naturally infected by Trypanosoma vivax after treatment with isometamidium chloride. | Castilho Neto, KJGA., et al. 2021. Rev Bras Parasitol Vet. 30: e020220. PMID: 33909833
- Isometamidium chloride alters redox status, down-regulates p53 and PARP1 genes while modulating at proteomic level in Drosophila melanogaster. | Dangabar Shadrack, A., et al. 2023. Drug Chem Toxicol. 1-11. PMID: 36883353
- The toxic effect of intravenous application of the trypanocide isometamidium (Samorin). | Schillinger, D., et al. 1985. Zentralbl Veterinarmed A. 32: 234-9. PMID: 3923742
- HPTLC and HPLC determination of isometamidium in the presence of its manufacturing and degradation impurities. | Tettey, JN., et al. 1998. J Pharm Biomed Anal. 17: 713-8. PMID: 9682154
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isometamidium Chloride Hydrochloride, 1 mg | sc-488298 | 1 mg | $385.00 | |||
Isometamidium Chloride Hydrochloride, 10 mg | sc-488298A | 10 mg | $2150.00 |