Molecular structure of Isohelenin, Inula sp.
Isohelenin, Inula sp.
Application:
Isohelenin, Inula sp. is a cell-permeable sesquiterpene lactone that acts as an irreversible inhibitor of NF-κB activation
Purity:
≥95%
Molecular Weight:
232.3
Molecular Formula:
C15H20O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable sesquiterpene lactone with anti-inflammatory properties. A highly specific, potent, irreversible inhibitor of NF-κB activation that prevents IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells.
Isohelenin, Inula sp. References
Sheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99. Mazor, R.L., et al. 2000. Cytokine 12, 239. Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375. Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288. Bork, P.M., et al. 1997. FEBS Lett. 402, 85.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isohelenin, Inula sp., 1 mg | sc-221769 | 1 mg | $442.00 |