Molecular structure of Isoguvacine·HCl, CAS Number: 68547-97-7
Isoguvacine·HCl (CAS 68547-97-7)
See product citations (2)
Alternate Names:
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Application:
Isoguvacine⋅HCl is an agonist of Gamma-amino butyric acid receptors
CAS Number:
68547-97-7
Molecular Weight:
163.6
Molecular Formula:
C6H9NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isoguvacine is an agonist of Gamma-amino butyric acid (GABA), the common inhibitory neurotransmitter of the central nervous system. Isoguvacine interactions have many similar biochemical features of GABA synaptic function, but has been found to be less potent and contains limited conformational flexibility. Radiolabeled isoguvacine ([3H]Isoguvacine) has proven useful in experiments to label GABA neurons and produces strong binding to presumed GABA storage sites.
Isoguvacine·HCl (CAS 68547-97-7) References
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- Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation. | Abdala, AP., et al. 2009. J Physiol. 587: 3539-59. PMID: 19491247
- GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. | Kimura, T., et al. 2010. FEBS Lett. 584: 1193-8. PMID: 20159020
- The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. | Viitanen, T., et al. 2010. J Physiol. 588: 1527-40. PMID: 20211979
- Noradrenaline-induced enhancement of oscillatory local field potentials in the mouse accessory olfactory bulb does not depend on disinhibition of mitral cells. | Leszkowicz, E., et al. 2012. Eur J Neurosci. 35: 1433-45. PMID: 22487171
- GABA is an inhibitory neurotransmitter in the neural circuit regulating metamorphosis in a marine snail. | Biscocho, D., et al. 2018. Dev Neurobiol. 78: 736-753. PMID: 29663674
- GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. | Kim, JK., et al. 2018. Nat Commun. 9: 4184. PMID: 30305619
- Regional difference in spontaneous firing inhibition by GABAA and GABAB receptors in nigral dopamine neurons. | Kim, Y., et al. 2018. Korean J Physiol Pharmacol. 22: 721-729. PMID: 30402033
- gamma-D-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice. | Croucher, MJ., et al. 1984. Brain Res. 322: 111-4. PMID: 6097331
- Retinal GABA neuron labelling with [3H]isoguvacine in different species. | Agardh, E. and Ehinger, B. 1983. Exp Eye Res. 36: 215-29. PMID: 6825739
- Isoguvacine binding, uptake, and release: relation to the GABA system. | White, WF. and Snodgrass, SR. 1983. J Neurochem. 40: 1701-8. PMID: 6854327
- Spinal GABA receptors mediate brain delta opioid analgesia in Swiss Webster mice. | Rady, JJ. and Fujimoto, JM. 1995. Pharmacol Biochem Behav. 51: 655-9. PMID: 7675839
- Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. | Hammond, DL. and Washington, JD. 1993. Eur J Pharmacol. 234: 255-62. PMID: 8387011
- Repression of gamma-aminobutyric acid type A receptor alpha1 polypeptide biosynthesis requires chronic agonist exposure. | Miranda, JD. and Barnes, EM. 1997. J Biol Chem. 272: 16288-94. PMID: 9195932
- Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat. | Kaneko, M. and Hammond, DL. 1997. J Pharmacol Exp Ther. 282: 928-38. PMID: 9262360
Inhibitor of:
BGT-1.Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoguvacine·HCl, 10 mg | sc-200451 | 10 mg | $27.00 | |||
Isoguvacine·HCl, 50 mg | sc-200451A | 50 mg | $112.00 |