Date published: 2026-4-5

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Isobutyl nitrite (CAS 542-56-3)

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Application:
Isobutyl nitrite is an ester of isobutanol and nitrous acid
CAS Number:
542-56-3
Purity:
95%
Molecular Weight:
103.12
Molecular Formula:
C4H9NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isobutyl nitrite is a chemical compound that functions as a vasodilator when used in experimental contexts. It acts by relaxing smooth muscle cells in vitro. This mechanism of action is achieved through the release of nitric oxide, which then activates guanylate cyclase in vascular smooth muscle cells. As a result, this activation leads to an increase in cyclic guanosine monophosphate (cGMP) levels, ultimately causing relaxation of the smooth muscle and vasodilation. Isobutyl nitrite′s function as a vasodilator is particularly relevant in research and development settings where the effects of vasodilation on various physiological processes are being investigated. Its mechanism of action at the molecular level provides insights into the regulation of vascular tone and blood flow, contributing to a deeper understanding of cardiovascular physiology.


Isobutyl nitrite (CAS 542-56-3) References

  1. Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations.  |  Kielbasa, WB., et al. 1999. J Chromatogr B Biomed Sci Appl. 734: 83-9. PMID: 10574193
  2. Pitfalls in the toxicological analysis of an isobutyl nitrite-adulterated coffee drink.  |  Seto, Y., et al. 2000. Anal Chem. 72: 5187-92. PMID: 11080862
  3. Isobutyl-nitrite-induced methemoglobinemia; treatment with an exchange blood transfusion during hyperbaric oxygenation.  |  Jansen, T., et al. 2003. Acta Anaesthesiol Scand. 47: 1300-1. PMID: 14616332
  4. Prechronic inhalation toxicity studies of isobutyl nitrite.  |  Gaworski, CL., et al. 1992. Fundam Appl Toxicol. 19: 169-75. PMID: 1516772
  5. Inhaled isobutyl nitrite inhibited macrophage inducible nitric oxide by blocking NFkappaB signaling and promoting degradation of inducible nitric oxide synthase-2.  |  Ponnappan, U., et al. 2004. Int Immunopharmacol. 4: 1075-82. PMID: 15222982
  6. Comparison of isobutyl nitrate and isobutyl nitrite: tolerance and cross-tolerance to glyceryl trinitrate.  |  Zimmermann, T., et al. 1991. Eur J Pharmacol. 192: 181-4. PMID: 1904032
  7. Indications from animal and chemical experiments of a carcinogenic role for isobutyl nitrite.  |  Mirvish, SS., et al. 1988. NIDA Res Monogr. 83: 39-49. PMID: 2902514
  8. Severe methemoglobinemia secondary to isobutyl nitrite toxicity: the case of the 'Gold Rush'.  |  Taylor, GM., et al. 2021. Oxf Med Case Reports. 2021: omaa136. PMID: 33614047
  9. 'Popper' induced methemoglobinemia.  |  Elgendy, F., et al. 2022. Proc (Bayl Univ Med Cent). 35: 385-386. PMID: 35518804
  10. Ventricular fibrillation in a 21-year-old after inhalation of an isobutyl nitrite 'popper' product.  |  Gooley, B., et al. 2023. Am J Emerg Med. 64: 204.e5-204.e7. PMID: 36369048
  11. Abuse of isobutyl nitrite inhalation (Rush) by adolescents.  |  Schwartz, RH. and Peary, P. 1986. Clin Pediatr (Phila). 25: 308-10. PMID: 3698454
  12. Drug-induced methaemoglobinaemia. Treatment issues.  |  Coleman, MD. and Coleman, NA. 1996. Drug Saf. 14: 394-405. PMID: 8828017

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isobutyl nitrite, 100 ml

sc-235398
100 ml
$67.00

Isobutyl nitrite, 500 ml

sc-235398A
500 ml
$247.00