Date published: 2026-5-4

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Isobavachalcone (CAS 20784-50-3)

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Alternate Names:
2',4',4-Trihydroxy-3'-[3''-methylbut-3''-enyl]chalcone
Application:
Isobavachalcone is an inhibitor of platelet aggregation
CAS Number:
20784-50-3
Purity:
≥97%
Molecular Weight:
324.40
Molecular Formula:
C20H20O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isobavachalcone is a naturally occurring chalcone compound extracted from the heartwood of the Fabaceae family, particularly identified in plants like Psoralea corylifolia. As a member of the chalcone class of flavonoids, it exhibits a distinctive structural framework that allows it to participate in various biochemical interactions. Notably, isobavachalcone has been studied for its ability to inhibit the activity of certain enzymes and proteins within cells. Its mechanism of action involves the modulation of signaling pathways and the inhibition of key enzymes involved in the biosynthesis of various cellular components. In research settings, isobavachalcone has been utilized to explore its bioactivity in non-clinical studies, particularly focusing on its role in modulating oxidative stress responses and regulating gene expression through its antioxidant properties. These studies often investigate how its presence affects the expression of genes related to oxidative stress and survival pathways in cells, providing insights into the cellular mechanisms that govern stress responses and homeostasis. Furthermore, isobavachalcone′s ability to interact with various biomolecules makes it an interesting candidate for studying the molecular basis of enzyme inhibition and the structural requirements for binding to different cellular targets, thereby contributing to a broader understanding of cellular function and regulation at the molecular level.


Isobavachalcone (CAS 20784-50-3) References

  1. Antioxidative components of Psoralea corylifolia (Leguminosae).  |  Haraguchi, H., et al. 2002. Phytother Res. 16: 539-44. PMID: 12237811
  2. Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.  |  Akihisa, T., et al. 2003. Cancer Lett. 201: 133-7. PMID: 14607326
  3. Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa.  |  Omisore, NO., et al. 2005. Braz J Med Biol Res. 38: 1087-94. PMID: 16007280
  4. Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.  |  Akihisa, T., et al. 2006. J Nat Prod. 69: 38-42. PMID: 16441065
  5. Isobavachalcone: an overview.  |  Kuete, V. and Sandjo, LP. 2012. Chin J Integr Med. 18: 543-7. PMID: 22772918
  6. Pharmacological review of isobavachalcone, a naturally occurring chalcone.  |  Wang, M., et al. 2021. Pharmacol Res. 165: 105483. PMID: 33577976
  7. Isobavachalcone suppresses the TRIF-dependent signaling pathway of Toll-like receptors.  |  Shin, S., et al. 2022. Arch Pharm (Weinheim). 355: e2100404. PMID: 34964142
  8. Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms.  |  Xing, N., et al. 2022. Phytother Res. 36: 3120-3142. PMID: 35684981
  9. Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.  |  Guo, Q., et al. 2023. Int Immunopharmacol. 119: 110102. PMID: 37087870
  10. Antiplatelet flavonoids from seeds of Psoralea corylifolia.  |  Tsai, WJ., et al. 1996. J Nat Prod. 59: 671-2. PMID: 8759164

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isobavachalcone, 1 mg

sc-202666
1 mg
$213.00