Isoalantolactone (CAS 470-17-7)

Isoalantolactone, also known as isohelenin, is a sesquiterpene lactone present in Inula with a wide range of biological activities. It may act to exhibit inhibitory effects on the proliferation of pancreatic cancer cells, specifically PANC-1, BxPC-3, and HPAC, with IC50 values of 40, 43, and 48 µM, respectively. Additionally, it induces apoptosis, causes cell cycle arrest at the S phase, and triggers the production of reactive oxygen species (ROS) in PANC-1 cells.In experiments with RAW 264.7 macrophages, isoalantolactone at concentrations of 4 and 8 µM has demonstrated the ability to reduce the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) induced by lipopolysaccharides (LPS).From a chemical perspective, isoalantolactone belongs to the class of organic compounds called eudesmanolides, secoeudesmanolides, and derivatives. These compounds are characterized by their structural basis on the eudesmanolide or secoeudesmanolide skeleton. Isoalantolactone is typically found in a solid form and is considered practically insoluble in water, exhibiting relative neutrality. In the cellular context, it predominantly localizes to the cell membrane and cytoplasm, as predicted from its logP value.