Molecular structure of Iso-olomoucine, CAS Number: 101622-50-8
Iso-olomoucine (CAS 101622-50-8)
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Alternate Names:
6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
Application:
Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases
CAS Number:
101622-50-8
Molecular Weight:
298.35
Molecular Formula:
C15H18N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Iso-olomoucine is a negative control compound for Olomoucine (sc-3509), a potent and selective inhibitor of Cdc2, Cdk and orther cyclinrelated kinases.
Iso-olomoucine (CAS 101622-50-8) References
- Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues. | Xue, L., et al. 2002. Biochem Pharmacol. 64: 441-9. PMID: 12147295
- Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. | Zhang, M., et al. 2004. Am J Pathol. 165: 843-53. PMID: 15331409
- Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. | Taylor, JR., et al. 2007. Proc Natl Acad Sci U S A. 104: 4147-52. PMID: 17360491
- Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. | Price, DA., et al. 2009. Mol Pharmacol. 76: 812-23. PMID: 19628755
- Inhibition of cyclin-dependent kinases by purine analogues. | Veselý, J., et al. 1994. Eur J Biochem. 224: 771-86. PMID: 7925396
- The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker. | Krucher, NA., et al. 1997. Cell Mol Neurobiol. 17: 495-507. PMID: 9353591
- The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. | Alessi, F., et al. 1998. Exp Cell Res. 245: 8-18. PMID: 9828096
- Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. | Fletcher, AI., et al. 1999. J Biol Chem. 274: 4027-35. PMID: 9933594
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Iso-olomoucine, 5 µg | sc-201528 | 5 µg | $81.00 | |||
Iso-olomoucine, 25 µg | sc-201528A | 25 µg | $353.00 |