scyllo-Inositol (CAS 488-59-5)
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Scyllo-Inositol, a cyclic polyol, is of particular interest in biochemical and neurological research due to its involvement in cellular signaling and membrane dynamics. It is extensively used as a model compound to study the stereochemical configuration effects on biological systems, as its structure differs from the more common myo-inositol. In neuroscientific research, scyllo-Inositol is employed to explore its influence on protein aggregation, providing valuable insights into protein misfolding and aggregation processes, which are relevant to understanding a variety of neurodegenerative conditions. Additionally, this compound is used in the study of phosphoinositide metabolism, which is pivotal for cell signaling pathways, including those involved in cell growth and survival. In the field of plant science, scyllo-Inositol is also utilized to investigate stress responses, as its accumulation in plants can be an indicator of adaptation to environmental stressors.
scyllo-Inositol (CAS 488-59-5) References
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- Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. | Kwon, YU., et al. 2003. Bioorg Med Chem Lett. 13: 2981-4. PMID: 12941316
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- Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. | Sun, Y., et al. 2008. Bioorg Med Chem. 16: 7177-84. PMID: 18635362
- Interconversion of myo- and scyllo-inositol with simultaneous formation of neo-inositol by an NADP+ dependent epimerase from bovine brain. | Hipps, PP., et al. 1977. Biochem Biophys Res Commun. 77: 340-6. PMID: 19018
- Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. | Choi, JK., et al. 2010. Neuropharmacology. 59: 353-7. PMID: 20399219
- Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures. | Nozadze, M., et al. 2011. Seizure. 20: 173-6. PMID: 21074457
- Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors. | Shaw, JE., et al. 2012. ACS Chem Neurosci. 3: 167-77. PMID: 22860186
- scyllo-Inositol promotes robust mutant Huntingtin protein degradation. | Lai, AY., et al. 2014. J Biol Chem. 289: 3666-76. PMID: 24352657
- A new-generation of Bacillus subtilis cell factory for further elevated scyllo-inositol production. | Tanaka, K., et al. 2017. Microb Cell Fact. 16: 67. PMID: 28431560
- A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes. | Lee, D., et al. 2017. Sci Rep. 7: 14125. PMID: 29074878
- myo-Inositol dehydrogenase and scyllo-inositol dehydrogenase from Lactobacillus casei BL23 bind their substrates in very different orientations. | Aamudalapalli, HB., et al. 2018. Biochim Biophys Acta Proteins Proteom. 1866: 1115-1124. PMID: 30282609
- In vivo evidence for decreased scyllo-inositol levels in the supplementary motor area of patients with Progressive Supranuclear Palsy: A proton MR spectroscopy study. | Barbagallo, G., et al. 2019. Parkinsonism Relat Disord. 62: 185-191. PMID: 30558837
- Single amino acid mutation altered substrate specificity for L-glucose and inositol in scyllo-inositol dehydrogenase isolated from Paracoccus laeviglucosivorans. | Suzuki, M., et al. 2020. Biosci Biotechnol Biochem. 84: 734-742. PMID: 31842701
- Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR. | Seaquist, ER. and Gruetter, R. 1998. Magn Reson Med. 39: 313-6. PMID: 9469716
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
scyllo-Inositol, 5 mg | sc-202808 | 5 mg | $72.00 | |||
scyllo-Inositol, 25 mg | sc-202808A | 25 mg | $220.00 |