Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

Isatropolone A

0.0(0)
Write a reviewAsk a question

Purity:
≥98%
Molecular Weight:
456.5
Molecular Formula:
C24H24O9
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Isatropolone A is a unique tricyclic polyketide derived from Streptomyces Go66. This compound has piqued the interest of researchers due to its unusual molecular structure and its implications for various biochemical processes. The focus of research on Isatropolone A has predominantly centered around its mechanisms of action in inhibiting the formation of biofilms and its potential as a quorum sensing inhibitor. Studies have detailed how Isatropolone A interacts with microbial communication systems. It appears to disrupt the signaling pathways that bacteria use to coordinate activity, such as biofilm formation and virulence factor production. This disruption is thought to occur through the modulation of signal molecules, which are crucial for bacterial population coordination. Furthermore, Isatropolone A has been studied for its antioxidant properties, where it demonstrates an ability to scavenge free radicals. This activity provides a basis for examining the compound′s potential role in oxidative stress-related processes. Research involving spectrophotometric assays and reactive oxygen species (ROS) measurements has been conducted to understand how Isatropolone A interacts with and neutralizes these molecules.


Isatropolone A References

  1. Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.  |  Cai, X., et al. 2017. Angew Chem Int Ed Engl. 56: 4945-4949. PMID: 28371116
  2. Isarubrolones Containing a Pyridooxazinium Unit from Streptomyces as Autophagy Activators.  |  Li, L., et al. 2019. J Nat Prod. 82: 1149-1154. PMID: 31070914
  3. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase.  |  Yan, Y., et al. 2020. Chem Sci. 11: 3959-3964. PMID: 34122866
  4. Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy.  |  Li, L., et al. 2022. J Antibiot (Tokyo). 75: 702-708. PMID: 36224376
  5. Engineering Streptomyces sp. CPCC 204095 for the targeted high-level production of isatropolone A by elucidating its pathway-specific regulatory mechanism.  |  Zhang, C., et al. 2024. Microb Cell Fact. 23: 113. PMID: 38622698

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isatropolone A, 1 mg

sc-364115
1 mg
$334.00

Isatropolone A, 5 mg

sc-364115A
5 mg
$1000.00