Molecular structure of Irsogladine maleate, CAS Number: 84504-69-8
Irsogladine maleate (CAS 84504-69-8)
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Application:
Irsogladine maleate is a PDE4 inhibitor and muscarinic acetylcholine receptor binder
CAS Number:
84504-69-8
Purity:
98%
Molecular Weight:
372.2
Molecular Formula:
C9H7Cl2N5•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Irsogladine maleate is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. It is a potent inhibitor of angiogenesis in wild-type and plasminogen activator-deficient mice. Inhibition of PDE4 prevents the hydrolysis of cAMP, an important secondary messenger molecule that is heavily involved in signal transduction. It enhances gap junction intercellular communication (GJIC) by promoting the transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells. These protective effects can be reversed by the nitric oxide synthase inhibitor L-NAME. Irsogladine maleate functions as an inhibitor of COX-1/2 and PDE.
Irsogladine maleate (CAS 84504-69-8) References
- Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. | Kawasaki, Y., et al. 2002. Pancreas. 25: 373-7. PMID: 12409832
- Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. | Kyoi, T., et al. 2004. Life Sci. 75: 1833-42. PMID: 15302227
- Irsogladine maleate regulates gap junctional intercellular communication-dependent epithelial barrier in human nasal epithelial cells. | Miyata, R., et al. 2015. J Membr Biol. 248: 327-36. PMID: 25652184
- Irsogladine Maleate Prevents Colitis in Interleukin-10 Gene-Deficient Mice by Reducing Interleukin-12 and -23 Production. | Nakagawa, T., et al. 2015. Biol Pharm Bull. 38: 1681-8. PMID: 26521820
- Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. | Onuma, W., et al. 2016. Oncotarget. 7: 8640-52. PMID: 26840084
- Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate. | Kawano, Y., et al. 2016. Chem Pharm Bull (Tokyo). 64: 1659-1665. PMID: 27628929
- A combination of irsogladine maleate and azithromycin exhibits addictive protective effects in LPS-induced human gingival epithelial cells. | Feng, X. and Liu, J. 2017. Pharmazie. 72: 91-94. PMID: 29441859
- Patient with oral lichen planus successfully treated with irsogladine maleate. | Katsue, H., et al. 2020. J Dermatol. 47: e56-e57. PMID: 31833090
- Gastroprotective effects of irsogladine maleate on ethanol/hydrochloric acid induced gastric ulcers in mice. | Kwon, SC. and Kim, JH. 2021. Korean J Intern Med. 36: 67-75. PMID: 31852177
- Irsogladine maleate alters expression of a tight junction protein in portal hypertensive gastropathy. | Yokoyama, K., et al. 2021. J Gastroenterol Hepatol. 36: 1208-1215. PMID: 32926748
- Protective Effect of Irsogladine against Aspirin-Induced Mucosal Injury in Human Induced Pluripotent Stem Cell-Derived Small Intestine. | Kanno, T., et al. 2022. Medicina (Kaunas). 59: PMID: 36676718
- Irsogladine is a potent inhibitor of angiogenesis. | Sato, Y., et al. 1993. FEBS Lett. 322: 155-8. PMID: 7683279
- Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. | Ren, CJ., et al. 1998. J Surg Res. 77: 126-31. PMID: 9733598
Inhibitor of:
Angiogenesis, and PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Irsogladine maleate, 50 mg | sc-201190 | 50 mg | $64.00 | |||
Irsogladine maleate, 250 mg | sc-201190A | 250 mg | $153.00 |