Date published: 2025-12-19

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Iron(III) citrate (CAS 3522-50-7)

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CAS Number:
3522-50-7
Molecular Weight:
244.95
Molecular Formula:
C6H5FeO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Iron(III) citrate hydrate is a coordination compound that combines iron and citrate in a hydrated form, and it is of interest across several research areas, particularly in the fields of biochemistry and environmental science. In biochemistry, it is often used as an iron source to study iron metabolism and the mechanisms of iron uptake in living organisms. Due to its solubility in water, iron(III) citrate hydrate is suitable for use in aqueous solutions, making it an excellent candidate for in vitro experiments requiring iron ions. In environmental chemistry, researchers explore its role in the bioremediation of contaminated sites, as it can be involved in the mobilization or immobilization of heavy metals in soil and groundwater. Iron(III) citrate hydrate is also used in the synthesis of iron oxide nanoparticles, which have applications in catalysis, magnetic resonance imaging (MRI), and as adsorbents for the removal of pollutants from water. Additionally, the study of iron-citrate complexes contributes to the understanding of iron transport and storage in natural water systems.


Iron(III) citrate (CAS 3522-50-7) References

  1. Differences in the uptake of iron from Fe(II) ascorbate and Fe(III) citrate by IEC-6 cells and the involvement of ferroportin/IREG-1/MTP-1/SLC40A1.  |  Thomas, C. and Oates, PS. 2004. Pflugers Arch. 448: 431-7. PMID: 15114483
  2. New trends in the chemistry of iron(III) citrate complexes: correlations between X-ray structures and solution species probed by electrospray mass spectrometry and kinetics of iron uptake from citrate by iron chelators.  |  Gautier-Luneau, I., et al. 2005. Chemistry. 11: 2207-19. PMID: 15719360
  3. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera.  |  Evans, RW., et al. 2008. J Biol Inorg Chem. 13: 57-74. PMID: 17906879
  4. Iron (III) citrate inhibits polyethylenimine-mediated transient transfection of Chinese hamster ovary cells in serum-free medium.  |  Eberhardy, SR., et al. 2009. Cytotechnology. 60: 1. PMID: 19557539
  5. Iron(III) citrate speciation in aqueous solution.  |  Silva, AM., et al. 2009. Dalton Trans. 8616-25. PMID: 19809738
  6. Revision of iron(III)-citrate speciation in aqueous solution. Voltammetric and spectrophotometric studies.  |  Vukosav, P., et al. 2012. Anal Chim Acta. 745: 85-91. PMID: 22938610
  7. Ferric citrate controls phosphorus and delivers iron in patients on dialysis.  |  Lewis, JB., et al. 2015. J Am Soc Nephrol. 26: 493-503. PMID: 25060056
  8. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.  |  Baba, Y., et al. 2018. Am J Physiol Heart Circ Physiol. 314: H659-H668. PMID: 29127238
  9. Chloroplasts preferentially take up ferric-citrate over iron-nicotianamine complexes in Brassica napus.  |  Müller, B., et al. 2019. Planta. 249: 751-763. PMID: 30382344
  10. Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats.  |  Iida, A., et al. 2020. J Vet Med Sci. 82: 379-386. PMID: 31996496
  11. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.  |  Hanudel, MR., et al. 2022. Kidney Int. 101: 711-719. PMID: 34838540
  12. New aspects of the photodegradation of iron(III) citrate: spectroscopic studies and plant-related factors.  |  Gracheva, M., et al. 2022. Photochem Photobiol Sci. 21: 983-996. PMID: 35199321
  13. Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.  |  Biruete, A., et al. 2022. Nephrol Dial Transplant. 37: 1857-1867. PMID: 35482713
  14. Ferric citrate for the treatment of hyperphosphatemia and anemia in patients with chronic kidney disease: a meta-analysis of randomized clinical trials.  |  Li, L., et al. 2022. Ren Fail. 44: 1112-1122. PMID: 35912897
  15. Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes.  |  Graham, RM., et al. 1998. J Hepatol. 29: 603-13. PMID: 9824270

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Iron(III) citrate, 100 g

sc-286019
100 g
$45.00

Iron(III) citrate, 250 g

sc-286019A
250 g
$85.00