Molecular structure of Ipsapirone, CAS Number: 95847-70-4
Ipsapirone (CAS 95847-70-4)
Alternate Names:
TVX Q 7821
Application:
Ipsapirone is a selective SR-1A agonist
CAS Number:
95847-70-4
Purity:
≥99%
Molecular Weight:
401.48
Molecular Formula:
C19H23N5O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ipsapirone, also known as TVX Q 7821, is a SR-1A agonist and has been found to selectively bind to SR-1 receptors. Only at high doses, this compound shows the ability to inhibit 1-adrenergic and SR-2 function. Exposure of ethanol treated rhombencephalic neurons to Ipsapirone has been reported to prevent ethanol-associated apoptosis of the cells and also activate the PI3K/Akt pro-survival pathway. Additionally, the expression of NF-kappaB dependent anti-apoptotic genes as well as Bcl-XL, catalase, and XIAP expression were augmented in the rhombencephalic neurons.
Ipsapirone (CAS 95847-70-4) References
- Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. | de Boer, SF., et al. 1999. J Pharmacol Exp Ther. 288: 1125-33. PMID: 10027850
- Neuroendocrine and behavioral responses during conditioned active and passive behavior in the defensive burying/probe avoidance paradigm: effects of ipsapirone. | Korte, SM., et al. 1992. Physiol Behav. 52: 355-61. PMID: 1355919
- Alteration of 5-HT1A receptor binding sites following chronic treatment with ipsapirone measured by quantitative autoradiography. | Fanelli, RJ. and McMonagle-Strucko, K. 1992. Synapse. 12: 75-81. PMID: 1357765
- Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. | Schechter, LE., et al. 1990. J Pharmacol Exp Ther. 255: 1335-47. PMID: 1702155
- Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. | Lee, JH., et al. 2009. Brain Res. 1249: 54-60. PMID: 18992726
- Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro. | Darrow, EJ., et al. 1990. Eur J Pharmacol. 175: 145-53. PMID: 1968842
- Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. | Chaouloff, F., et al. 1990. Eur J Pharmacol. 177: 107-10. PMID: 2340854
- Alterations of central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine1A agonists with potential anxiolytic properties. | Hamon, M., et al. 1988. J Pharmacol Exp Ther. 246: 745-52. PMID: 2457083
- Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. | Maj, J., et al. 1987. J Neural Transm. 70: 1-17. PMID: 2889795
- Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. | Glaser, T. and Traber, J. 1985. Naunyn Schmiedebergs Arch Pharmacol. 329: 211-5. PMID: 3160954
- Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. | Traber, J., et al. 1984. Brain Res Bull. 12: 741-4. PMID: 6541079
- Anxiolytic effect of the 5-HT1A compounds 8-hydroxy-2-(di-n-propylamino) tetralin and ipsapirone in the social interaction paradigm: evidence of a presynaptic action. | Picazo, O., et al. 1995. Brain Res Bull. 37: 169-75. PMID: 7606493
- Neurotrophic effects of ipsapirone and other 5-HT1A receptor agonists on septal cholinergic neurons in culture. | Riad, M., et al. 1994. Brain Res Dev Brain Res. 82: 245-58. PMID: 7842512
- Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. | Schreiber, R. and De Vry, J. 1993. Eur J Pharmacol. 249: 341-51. PMID: 7904566
- Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. | Dong, J., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 303-11. PMID: 9303566
Inhibitor of:
Apoptosis.Activator of:
Serotonin, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ipsapirone, 10 mg | sc-203607 | 10 mg | $129.00 | |||
Ipsapirone, 50 mg | sc-203607A | 50 mg | $525.00 |