IPO-38 Antibody (IPO-38): sc-52430

IPO-38 Antibody (IPO-38) is a mouse monoclonal IgM antibody that detects IPO-38 protein of mouse, rat, and human origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). IPO-38 (IPO-38) antibody is available in non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). IPO-38 protein, also known as non-lineage 116 (N-L116), is primarily located in nuclei of proliferating cells, which is crucial for its role as a proliferation marker. Nuclear presence indicates active cell division, making IPO-38 (IPO-38) monoclonal antibody a valuable tool for studying cancer biology, particularly in various forms of leukemia, Hodgkin′s disease, non-Hodgkin′s lymphomas, and solid tumors such as breast and colorectal carcinomas. IPO-38 is upregulated in gastric cancer, serving as a promising biomarker for predicting patient prognosis. Sequence analysis of IPO-38 antigen, immunoprecipitated from gastric cancer cell lines, suggests IPO-38 may represent a modified form of Histone H2B antigen, linking IPO-38 to critical cellular processes such as gene regulation and chromatin remodeling. Nuclear IPO-38 detection in human and murine lymphoid and non-lymphoid cell lines, while absent in mononuclear cells and granulocytes from healthy donors, underscores IPO-38 (IPO-38) antibody′s potential utility in monitoring tumor progression and therapeutic response.

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IPO-38 Antibody (IPO-38) References:

1. A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and ameloblastoma.  |  Thosaporn, W., et al. 2004. Oral Dis. 10: 22-6. PMID: 14996290
2. Chromatin modifying activity of leukaemia associated fusion proteins.  |  Di Croce, L. 2005. Hum Mol Genet. 14 Spec No 1: R77-84. PMID: 15809276
3. Acute promyelocytic leukemia: a model of molecular target based therapy.  |  Zhou, GB., et al. 2005. Hematology. 10 Suppl 1: 270-80. PMID: 16188687
4. IPO-38 is identified as a novel serum biomarker of gastric cancer based on clinical proteomics technology.  |  Hao, Y., et al. 2008. J Proteome Res. 7: 3668-77. PMID: 18680356
5. [Monoclonal antibodies of the IPO series in studying and diagnosing malignant lymphoproliferative diseases].  |  Sidorenko, SP., et al. 1990. Gematol Transfuziol. 35: 19-22. PMID: 2373343

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IPO-38 Antibody (IPO-38) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IPO-38 Antibody (IPO-38) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IPO-38 Antibody (IPO-38) Specifications

Alternate Product Name: IPO-38

Product Clone Name: IPO-38

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: IPO-38

Epitope Species: human

Product Reactivity/Detection: IPO-38

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IPO-38 Antibody (IPO-38): FITC: Fluoroscein, PE: Phycoerythrin