IP3K Inhibitor Inhibitor (CAS 519178-28-0)
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IP3K Inhibitor is a cell-permeable 2,6-disubstituted purine compound that acts as a selective, ATP-competitive inhibitor of IP 3-K (IC50 = 10.2 µM), the kinase that catalyzes the conversion of IP3 to IP4. Induces elevated cellular IP3 level and Ca2+-release in a dose-dependent manner (5 to 20 µM in HL60 cells). IP3K Inhibitor exhibits negligible inhibitory effect on Cdk1 (IC50 >100 µM) and two other IP3 metabolizing enzymes, PLC and IP3 5-ppase, even at concentrations as high as 200 µM. IP3K Inhibitor is a useful alternative to the non-cell-permeable IP3 or IP3 analogs for studies involving intact cells. IP3K inhibitors belong to a group of compounds that hinder the function of inositol-3-phosphate kinase (IP3K). IP3K plays a vital role in regulating the concentration of inositol-3-phosphate (IP3) within cells, which acts as a signaling molecule involved in numerous cellular processes.
IP3K Inhibitor Inhibitor (CAS 519178-28-0) References
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- TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway. | Ghoshal, S., et al. 2016. Mol Metab. 5: 903-917. PMID: 27689003
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IP3K Inhibitor, 5 mg | sc-204015 | 5 mg | $195.00 |