Molecular structure of Iopanoic Acid, CAS Number: 96-83-3
Iopanoic Acid (CAS 96-83-3)
Alternate Names:
3-Amino-α-ethyl-2,4,6-triiodohydrocinnamic acid; 2-(3-Amino-2,4,6-triiodobenzyl)butyric acid; 3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropionic acid; Iodopanoic acid
CAS Number:
96-83-3
Molecular Weight:
570.94
Molecular Formula:
C11H12I3NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Iopanoic acid has found extensive application in various scientific research endeavors. Its in vitro usage entails investigating the impact of bile acids on drug absorption within cell cultures and examining how bile acids influence the growth and development of bacteria. The proposed mechanism of action for iopanoic acid involves its affinity for bile acid receptors, which are present on the cellular surface of organs such as the liver and intestine. Upon binding to these receptors, iopanoic acid initiates a series of biochemical reactions that modulate the absorption and metabolism of cholesterol and other lipids.
Iopanoic Acid (CAS 96-83-3) References
- Iopanoic acid-induced decrease of circulating T3 causes a significant increase in GH responsiveness to GH releasing hormone in thyrotoxic patients. | Ramos-Dias, JC. and Lengyel, AM. 1999. Clin Endocrinol (Oxf). 51: 461-7. PMID: 10583313
- Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy. | Bogazzi, F., et al. 2002. J Endocrinol Invest. 25: 176-80. PMID: 11929091
- Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. | Bogazzi, F., et al. 2003. J Clin Endocrinol Metab. 88: 1999-2002. PMID: 12727944
- Treatment of hyperthyroidism associated with thyrotropin-secreting pituitary adenomas with iopanoic acid. | Dhillon, KS., et al. 2004. J Clin Endocrinol Metab. 89: 708-11. PMID: 14764785
- Effects and safety of iopanoic acid in cats administered levothyroxine. | Gallagher, AE. and Panciera, DL. 2009. J Feline Med Surg. 11: 69-75. PMID: 18786844
- Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosis. | Matrka, L., et al. 2008. Ear Nose Throat J. 87: 702-4. PMID: 19105148
- Efficacy of iopanoic acid for treatment of spontaneous hyperthyroidism in cats. | Gallagher, AE. and Panciera, DL. 2011. J Feline Med Surg. 13: 441-7. PMID: 21515081
- Identification of iopanoic acid as substrate of type 1 deiodinase by a novel nonradioactive iodide-release assay. | Renko, K., et al. 2012. Endocrinology. 153: 2506-13. PMID: 22434082
- Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid. | Cavallin, JE., et al. 2017. Environ Toxicol Chem. 36: 2942-2952. PMID: 28488362
- Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid. | Haselman, JT., et al. 2022. Toxicol Sci. 187: 139-149. PMID: 35179606
Inhibitor of:
DIO1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Iopanoic Acid, 5 g | sc-487694 | 5 g | $397.00 | |||
Iopanoic Acid, 25 g | sc-487694A | 25 g | $1385.00 |