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Ionomycin calcium salt (1 mM solution in DMSO) (CAS 56092-82-1)

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Alternate Names:
Ionomycin calcium salt (1 mM solution in DMSO) is known as a selective calcium ionophore.
Application:
Ionomycin calcium salt (1 mM solution in DMSO) is a selective ionophore and an ion carrier for Ca2+.
CAS Number:
56092-82-1
Purity:
≥98%
Molecular Weight:
747.07
Molecular Formula:
C41H70CaO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ionomycin calcium salt (1 mM solution in DMSO) is a selective calcium ionophore that mobilizes calcium stores within the cell. It is used to raise the level of calcium within a cell. In addition, Ionomycin calcium salt (1 mM solution in DMSO) can be used in the study of calcium membrane penetration, and cytokine stimulation intracellularly. Ionomycin calcium salt (1 mM solution in DMSO) is an ionophore that may act to be more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent and induces apoptotic degeneration of embryonic cortical neurons.


Ionomycin calcium salt (1 mM solution in DMSO) (CAS 56092-82-1) References

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  2. Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis.  |  Yoshida, S. and Plant, S. 1992. J Physiol. 458: 307-18. PMID: 1302268
  3. Increase of cytosolic calcium induced by trichosanthin suppresses cAMP/PKC levels through the inhibition of adenylyl cyclase activity in HeLa cells.  |  Jiang, Q., et al. 2011. Mol Biol Rep. 38: 2863-8. PMID: 21088904
  4. Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach.  |  Albano, GD., et al. 2013. PLoS One. 8: e58892. PMID: 23573194
  5. In situ fiber-optical monitoring of cytosolic calcium in tissue explant cultures.  |  Ryser, M., et al. 2015. J Biophotonics. 8: 183-95. PMID: 24026906
  6. Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination.  |  Brambilla, R., et al. 2014. Glia. 62: 452-67. PMID: 24357067
  7. Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus Vectors.  |  Calcedo, R., et al. 2018. Hum Gene Ther Methods. 29: 86-95. PMID: 29668327
  8. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties.  |  Du, L., et al. 2019. Cell Metab. 29: 1363-1375.e8. PMID: 30745181
  9. A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation.  |  Saadi, W., et al. 2019. Sci Rep. 9: 4707. PMID: 30886319
  10. Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice.  |  Matsuda, M., et al. 2019. J Pharmacol Sci. 141: 139-145. PMID: 31744690
  11. Endocytic BDNF secretion regulated by Vamp3 in astrocytes.  |  Han, J., et al. 2021. Sci Rep. 11: 21203. PMID: 34707216
  12. Studying Unconventional Secretion of Misfolded Proteins in Cultured Cells and Primary Neurons.  |  Lee, J. and Ye, Y. 2022. Methods Mol Biol. 2473: 349-366. PMID: 35819775
  13. Ionomycin, a new polyether antibiotic.  |  Liu, WC., et al. 1978. J Antibiot (Tokyo). 31: 815-9. PMID: 711623
  14. Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane.  |  Morgan, AJ. and Jacob, R. 1994. Biochem J. 300 (Pt 3): 665-72. PMID: 8010948
  15. Structure Of Ionomycin - A Novel Diacidic Polyether Antibiotic Having High Affinity For Calcium Ions  |  Barbara K. Toeplitz, et al. 1979. Journal of the American Chemical Society. 101: 3344–3353.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ionomycin calcium salt (1 mM solution in DMSO), 1 ml

sc-300835
1 ml
$168.00