Date published: 2025-9-23

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Iodosobenzene (CAS 536-80-1)

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Alternate Names:
Iodosylbenzene
Application:
Iodosobenzene is an iodinated benzene compound for proteomics research
CAS Number:
536-80-1
Purity:
≥95%
Molecular Weight:
220.01
Molecular Formula:
C6H5IO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Iodosobenzene is an organoiodine compound with a solid, colorless form, employed as a reagent in organic synthesis. Its versatility as a reagent enables its application in various scenarios, including the synthesis of diverse organic compounds and the production of polymers. Additionally, iodosobenzene finds utility in the synthesis of organometallic compounds, the oxidation of alcohols, and the creation of a wide range of other organic compounds.


Iodosobenzene (CAS 536-80-1) References

  1. Chemoselective C-H oxidation of alcohols to carbonyl compounds with iodosobenzene catalyzed by (salen)chromium complex.  |  Adam, W., et al. 2000. J Org Chem. 65: 1915-8. PMID: 10774009
  2. The influence of dioxygen on luminol chemiluminescence.  |  Baj, S., et al. 2009. Luminescence. 24: 348-54. PMID: 19294631
  3. A mild and efficient direct α-amination of β-dicarbonyl compounds using iodosobenzene and p-toluenesulfonamide catalyzed by perchlorate zinc hexahydrate.  |  Yu, J., et al. 2012. Org Lett. 14: 832-5. PMID: 22260345
  4. Synthesis of highly substituted oxazoles through iodine(III)-mediated reactions of ketones with nitriles.  |  Saito, A., et al. 2012. Molecules. 17: 11046-55. PMID: 22976468
  5. Indole synthesis based on a modified Koser reagent.  |  Fra, L., et al. 2014. Angew Chem Int Ed Engl. 53: 7349-53. PMID: 24890610
  6. Pd-Catalyzed Ligand-Free Synthesis of Arylated Heteroaromatics by Coupling of N-Heteroaromatic Bromides with Iodobenzene Diacetate, Iodosobenzene, or Diphenyliodonium Salts.  |  Wang, X., et al. 2016. J Org Chem. 81: 7958-62. PMID: 27458647
  7. Hypervalent Iodine(III)-Mediated Oxidative Fluorination of Alkylsilanes by Fluoride Ions.  |  Xu, P., et al. 2017. Angew Chem Int Ed Engl. 56: 1101-1104. PMID: 27966813
  8. The role of O(1D) in the oxidation mechanism of ethylene by iodosobenzene and other hypervalent molecules.  |  Khan, SN. and Miliordos, E. 2017. Phys Chem Chem Phys. 19: 18152-18155. PMID: 28692086
  9. On the mechanism of action of cytochrome P-450. Spectral intermediates in the reaction with iodosobenzene and its derivatives.  |  Blake, RC. and Coon, MJ. 1989. J Biol Chem. 264: 3694-701. PMID: 2917971
  10. Computational Investigation into the Mechanistic Features of Bromide-Catalyzed Alcohol Oxidation by PhIO in Water.  |  Farshadfar, K., et al. 2021. J Org Chem. 86: 2998-3007. PMID: 33502190
  11. Accessing Boron-Doped Pentaphene Analogues from 12-Boradibenzofluorene.  |  Akram, MO., et al. 2022. Inorg Chem. 61: 9595-9604. PMID: 35696381
  12. Enantioselective N-Heterocyclic Carbene Catalyzed α-Oxidative Coupling of Enals with Carboxylic Acids Using an Iodine(III) Reagent.  |  Xu, YY., et al. 2023. Angew Chem Int Ed Engl. 62: e202218362. PMID: 36651829
  13. Synthesis of 21-hydroxy-11,19-oxidopregn-4-ene-3,20-dione and 21-hydroxy-6,19-oxidopregn-4-ene-3,20-dione.  |  Veleiro, AS., et al. 1995. Steroids. 60: 268-71. PMID: 7792830

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Iodosobenzene, 5 g

sc-295188
5 g
$377.00