Iodophenpropit dihydrobromide (CAS 145196-87-8)
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Iodophenpropit dihydrobromide (IPPB) functions as a selective histamine H3 receptor antagonist, it finds common use in scientific research applications. Iodophenpropit dihydrobromide allows for the investigation of histamine H3 receptor activation effects through in vitro studies. In vitro studies, on the other hand, have employed Iodophenpropit dihydrobromide to investigate the effects of histamine H3 receptor activation on various cell cultures, including neuronal cells, smooth muscle cells, and endothelial cells. Acting as a selective histamine H3 receptor antagonist, Iodophenpropit dihydrobromide effectively binds to the histamine H3 receptor, hindering the binding of endogenous histamine and preventing receptor activation. Consequently, downstream effects associated with histamine H3 receptor activation, such as neurotransmitter release and signal transduction pathway activation, are impeded.
Iodophenpropit dihydrobromide (CAS 145196-87-8) References
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- Immunological, biochemical and histopathological evaluation of histamine receptors (H1R, H2R, H3R and H4R)-antagonist in rabbit experimental model: a short term study. | Tripathi, T., et al. 2012. Exp Toxicol Pathol. 64: 259-66. PMID: 20869857
- Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits. | Tripathi, T., et al. 2013. Bratisl Lek Listy. 114: 675-81. PMID: 24329504
- Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. | Mena-Avila, E., et al. 2018. Pharmacol Rep. 70: 146-155. PMID: 29414147
- [3H]-thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex. | Alves-Rodrigues, A., et al. 1996. Br J Pharmacol. 118: 2045-52. PMID: 8864541
- Pharmacological characterisation of the histamine H3 receptor in the rat hippocampus. | Alves-Rodrigues, A., et al. 1998. Brain Res. 788: 179-86. PMID: 9555002
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Iodophenpropit dihydrobromide, 10 mg | sc-361213 | 10 mg | $152.00 | |||
Iodophenpropit dihydrobromide, 50 mg | sc-361213A | 50 mg | $643.00 |