Date published: 2026-4-3

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Iodoacetonitrile (CAS 624-75-9)

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CAS Number:
624-75-9
Molecular Weight:
166.95
Molecular Formula:
C2H2IN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Iodoacetonitrile is extensively researched within chemical synthesis, particularly for its role as an alkylating agent in the formation of carbon-nitrogen bonds. This compound is pivotal in studies involving nucleophilic substitution reactions where it acts as a versatile precursor for the synthesis of various organic compounds, including agrochemicals. The reactivity of Iodoacetonitrile under different conditions is a key area of investigation, as it influences the efficiency and selectivity of these reactions. Researchers also focus on the mechanisms by which Iodoacetonitrile interacts with other molecules, aiming to elucidate the pathways and improve reaction outcomes. Additionally, the stability and handling safety of Iodoacetonitrile are examined to optimize its use in laboratory and industrial settings.


Iodoacetonitrile (CAS 624-75-9) References

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  2. Haloacetonitriles vs. regulated haloacetic acids: are nitrogen-containing DBPs more toxic?  |  Muellner, MG., et al. 2007. Environ Sci Technol. 41: 645-51. PMID: 17310735
  3. Intermolecular nonreductive alkylation of enamides via radical-polar crossover.  |  Friestad, GK. and Wu, Y. 2009. Org Lett. 11: 819-22. PMID: 19199766
  4. Occupational erythema multiforme-like contact reaction to iodoacetonitrile in a chemistry student.  |  Foti, C., et al. 2011. Contact Dermatitis. 64: 180-1. PMID: 21272032
  5. Toxicity of drinking water disinfection byproducts: cell cycle alterations induced by the monohaloacetonitriles.  |  Komaki, Y., et al. 2014. Environ Sci Technol. 48: 11662-9. PMID: 25185076
  6. Cyanoacetic Acid as a Masked Electrophile: Transition-Metal-Free Cyanomethylation of Amines and Carboxylic Acids.  |  Wang, H., et al. 2015. Chemistry. 21: 18333-7. PMID: 26511114
  7. Visible-Light-Induced Regioselective Cyanomethylation of Imidazopyridines and Its Application in Drug Synthesis.  |  Chang, Q., et al. 2017. J Org Chem. 82: 5391-5397. PMID: 28470069
  8. Chlorination of Source Water Containing Iodinated X-ray Contrast Media: Mutagenicity and Identification of New Iodinated Disinfection Byproducts.  |  Postigo, C., et al. 2018. Environ Sci Technol. 52: 13047-13056. PMID: 30339747
  9. Comparative Quantitative Toxicology and QSAR Modeling of the Haloacetonitriles: Forcing Agents of Water Disinfection Byproduct Toxicity.  |  Wei, X., et al. 2020. Environ Sci Technol. 54: 8909-8918. PMID: 32551543
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  12. Diastereoselective palladium-catalyzed C(sp3)-H cyanomethylation of amino acid and carboxylic acid derivatives.  |  Garai, S., et al. 2022. Chem Commun (Camb). 58: 7793-7796. PMID: 35735087
  13. NRF2-ARE signaling is responsive to haloacetonitrile-induced oxidative stress in human keratinocytes.  |  Xue, P., et al. 2022. Toxicol Appl Pharmacol. 450: 116163. PMID: 35842135
  14. Overlooked Iodo-Disinfection Byproduct Formation When Cooking Pasta with Iodized Table Salt.  |  Dong, H., et al. 2023. Environ Sci Technol. 57: 3538-3548. PMID: 36802504
  15. Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.  |  Huang, GF., et al. 1981. J Med Chem. 24: 390-3. PMID: 6267280

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Iodoacetonitrile, 10 g

sc-250160
10 g
$92.00