Molecular structure of Iodoacetic acid sodium salt, CAS Number: 305-53-3
Iodoacetic acid sodium salt (CAS 305-53-3)
Alternate Names:
Sodium iodoacetate
Application:
Iodoacetic acid sodium salt is a reagent used to modify cysteine residues in proteins to inhibit cysteine proteases.
CAS Number:
305-53-3
Purity:
≥98%
Molecular Weight:
207.93
Molecular Formula:
C2H2IO2•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Iodoacetic acid sodium salt, also known as sodium iodoacetate, is a chemical compound widely used in biochemistry and laboratory research for its ability to modify cysteine residues in proteins and inhibit cysteine proteases. This compound demonstrates a minor inhibitory effect on specific enzymatic activities in hen plasma. It is characterized by its solubility in water and alcohol, appearing as a white solid. Its role extends to various research applications, such as enzyme studies, protein structure and metabolism analysis, and the exploration of cellular processes including cell signaling and sodium channel functionality. Iodoacetic acid sodium salt′s capacity to bind to enzyme active sites, obstructing their catalytic functions, makes it useful in understanding protein and cellular mechanisms, DNA and RNA synthesis, and gene expression.
Iodoacetic acid sodium salt (CAS 305-53-3) References
- In vitro insulin refolding: characterization of the intermediates and the putative folding pathway. | Tang, Y., et al. 2007. Sci China C Life Sci. 50: 717-25. PMID: 17914645
- Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells. | Bongard, RD., et al. 2009. Free Radic Biol Med. 46: 25-32. PMID: 18848878
- Synthesis and evaluation of novel photoreactive alpha-amino acid analog carrying acidic and cleavable functions. | Bongo, NB., et al. 2009. Bioorg Med Chem Lett. 19: 80-2. PMID: 19026535
- Development of an ultrathin sheet plastination technique in rat humeral joints with osteoarthritis induced by monosodium iodoacetate for neovascularization study. | Vargas, CA., et al. 2020. Anat Sci Int. 95: 297-303. PMID: 31401788
- Physicochemical properties of charge isomers of recombinant human superoxide dismutase. | Kajihara, J., et al. 1988. J Biochem. 104: 638-42. PMID: 3241003
- Reduction and reoxidation of the neurotoxin II from the scorpion Androctonus australis Hector. | Sabatier, JM., et al. 1987. Int J Pept Protein Res. 30: 125-34. PMID: 3667073
- Interaction between trypsin-like enzyme from Streptomyces erythraeus and chicken ovomucoid. | Nagata, K. and Yoshida, N. 1984. J Biochem. 96: 1041-9. PMID: 6394596
- Single hydrolysis method for all amino acids, including cysteine and tryptophan. | Inglis, AS. 1983. Methods Enzymol. 91: 26-36. PMID: 6855579
- Simultaneous detection of two mechanisms of immune destruction of penicillin-treated human red blood cells. | Yust, I., et al. 1982. Am J Hematol. 13: 53-62. PMID: 7137166
- Effect of some metallic cations and organic compounds on the O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma. | Sogorb, MA., et al. 1993. Arch Toxicol. 67: 416-21. PMID: 8215911
- Metabolic inhibitors and chromosome rejoining | AV Beatty, JW Beatty - American Journal of Botany, 1959 - Wiley Online Library. May 1959. American Journal of Botany. Volume46, Issue5: Pages 317-323.
- Equilibrium Folding of Porcine Insulin Precursor in the Presence of Redox Buffer: Implications for the Common Intermediates Shared by Its Unfolding/ Refolding Processes | , et al. 2008,. Protein and Peptide Letters,. Volume 15, Number 9,: pp. 972-979(8).
- Characterization of an intact phycoerythrin and its cleaved 14 kDa functional subunit from marine cyanobacterium Phormidium sp. A27DM | A Parmar, NK Singh, A Kaushal, D Madamwar - Process Biochemistry, 2011 - Elsevier. September 2011,. Process Biochemistry. Volume 46, Issue 9,: Pages 1793-1799.
Inhibitor of:
Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Iodoacetic acid sodium salt, 25 g | sc-204014 | 25 g | $123.00 |