Intercalated DNA Antibody (401): sc-66059
- Intercalated DNA Antibody (401) is a mouse monoclonal IgG2b Intercalated DNA antibody provided at 100 µg/ml
- raised against ethidium bromide intercalated calf thymus DNA
- recommended for detection of intercalated DNA by WB; non cross-reactive with single or double-stranded DNA or with ethidium bromide
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Intercalated DNA Antibody (401). This work is in progress.
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Intercalated DNA Antibody (401) is a mouse monoclonal IgG2b antibody that detects Intercalated DNA protein of non-species reactive by western blotting (WB). Anti-Intercalated DNA antibody (401) is available as a non-conjugated format, providing researchers with a reliable tool for studying interactions between DNA and various ligands. Intercalated DNA (401) monoclonal antibody enables investigation of DNA structural integrity, which can be affected by intercalating agents inserting between DNA double helix base pairs. This interaction can lead to alterations in DNA replication and transcription processes, impacting cellular functions and gene expression. Intercalating agents, such as ethidium bromide and doxorubicin, can disrupt normal DNA structure, leading to potential therapeutic applications in cancer treatment, particularly in targeting rapidly dividing cells. Anti-Intercalated DNA antibody (401) helps researchers gain insights into DNA damage and repair mechanisms, as well as effects of various ligands on DNA stability and function, making this antibody valuable for molecular biology and cancer research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Intercalated DNA Antibody (401) References:
- Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III. | Yakovleva, L., et al. 2006. Biochemistry. 45: 7644-53. PMID: 16768460
- The intercalation of DNA double helices with doxorubicin and nogalamycin. | Box, VG. 2007. J Mol Graph Model. 26: 14-9. PMID: 17046298
- Synthetic metallomolecules as agents for the control of DNA structure. | Richards, AD. and Rodger, A. 2007. Chem Soc Rev. 36: 471-83. PMID: 17325786
- Small molecule intercalation with double stranded DNA: implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals. | Hendry, LB., et al. 2007. Mutat Res. 623: 53-71. PMID: 17449065
- The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments [corrected]. | Choi, S., et al. 2007. J Biol Chem. 282: 36024-36. PMID: 17925400
- Ultrafast excited-state dynamics of oxazole yellow DNA intercalators. | Fürstenberg, A. and Vauthey, E. 2007. J Phys Chem B. 111: 12610-20. PMID: 17929857
- Supramolecular complex formation by beta-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded DNA and improved electrochemical gene detection. | Sato, S., et al. 2005. Molecules. 10: 693-707. PMID: 18007339
- Computer simulation study of the structural stability and materials properties of DNA-intercalated layered double hydroxides. | Thyveetil, MA., et al. 2008. J Am Chem Soc. 130: 4742-56. PMID: 18345669
- 3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat. | Wang, Y., et al. 2008. Chem Res Toxicol. 21: 1348-58. PMID: 18549249
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Intercalated DNA Antibody (401) | sc-66059 | 100 µg/ml | $322.00 |