Integrin β1d/ITGB1 Antibody (2B1): sc-59973

Integrin βId Antibody (2B1) is a mouse monoclonal IgG1 antibody that detects Integrin beta Id protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Integrin beta Id antibody (2B1) is available as the non-conjugated format. Integrin beta Id protein plays a crucial role in cell adhesion and signaling, functioning as a key mediator in the interaction between cells and the extracellular matrix. Integrin beta Id protein is primarily located on the cell surface, where Integrin beta Id forms heterodimers with various alpha subunits, allowing for the formation of multiple integrin receptors that can bind to a variety of ligands, including fibronectin and collagen. Integrin beta Id interaction with these ligands is essential for processes such as cell migration, proliferation, and survival, making Integrin beta Id a vital component in tissue development and repair. Furthermore, clustering of integrins upon ligand binding initiates intracellular signaling cascades that influence cellular behavior, highlighting Integrin beta Id importance in maintaining cellular homeostasis and responding to environmental cues. With broad species reactivity and versatile applications, Integrin beta Id monoclonal antibody (2B1) is an invaluable tool for researchers studying integrin-mediated processes in various biological contexts.

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Integrin β1d/ITGB1 Antibody (2B1) References:

1. Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3.  |  Hantgan, RR., et al. 2003. J Biol Chem. 278: 3417-26. PMID: 12426312
2. Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2.  |  Goncalves, I., et al. 2003. J Biol Chem. 278: 34812-22. PMID: 12832405
3. SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.  |  Maxwell, MJ., et al. 2004. J Biol Chem. 279: 32196-204. PMID: 15166241
4. Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling.  |  Huang, CL., et al. 2004. J Biol Chem. 279: 42279-89. PMID: 15280374
5. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
6. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
7. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
8. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
9. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β1d/ITGB1 Antibody (2B1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β1d/ITGB1 Antibody (2B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β1d/ITGB1 Antibody (2B1) Specifications

Alternate Product Name: Integrin βId

Product Clone Name: 2B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Integrin βId

Epitope Species: human

Product Reactivity/Detection: Integrin βId

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Integrin β1d/ITGB1 Antibody (2B1): N/A