Integrin β5/ITGB5 Antibody (B-1): sc-393866

Integrin β5 Antibody (B-1) is a mouse monoclonal IgM antibody that detects Integrin β5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin β5 plays a crucial role in cell adhesion and signaling, functioning as a receptor that interacts with various extracellular matrix components, including fibronectin and vitronectin. Integrin β5 is primarily located on the cell surface, where anti-Integrin β5 antibody (B-1) can detect heterodimer formation with α subunits, facilitating the attachment of cells to the extracellular matrix and promoting cellular communication. Integrin β5′s location enables mediation of both adhesion and signal transduction, influencing critical biological processes such as cell migration, proliferation, and survival. Through clustering with other integrins upon ligand binding, Integrin β5 activates intracellular signaling pathways essential for maintaining tissue integrity and responding to environmental cues. Anti-Integrin β5 antibody (B-1) serves as an invaluable tool for researchers studying these vital processes in various biological contexts.

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Integrin β5/ITGB5 Antibody (B-1) References:

1. ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.  |  Himes, BE., et al. 2013. BMC Med Genet. 14: 86. PMID: 23984888
2. Using CRISPRa and CRISPRi Technologies to Study the Biological Functions of ITGB5, TIMP1, and TMEM176B in Prostate Cancer Cells.  |  Yang, Y., et al. 2021. Front Mol Biosci. 8: 676021. PMID: 34109215
3. ITGB5 mutation discovered in a Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome.  |  Cheng, T., et al. 2021. Open Life Sci. 16: 1268-1277. PMID: 34966851
4. Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer.  |  Liu, D., et al. 2021. Front Cell Dev Biol. 9: 816230. PMID: 35223869
5. ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.  |  Wen, X., et al. 2022. Front Oncol. 12: 887068. PMID: 36249018
6. Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.  |  Gu, L., et al. 2023. Pharmacol Res. 192: 106789. PMID: 37149115
7. Corrigendum: ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.  |  Wen, X., et al. 2024. Front Oncol. 14: 1381151. PMID: 38463236
8. ITGB5 facilitates gastric cancer metastasis by promoting TGFBR2 endosomal recycling.  |  Lei, T., et al. 2024. Cancer Lett. 592: 216953. PMID: 38729557
9. ROS-mediated ITGB5 promotes tongue squamous cell carcinoma metastasis through epithelial mesenchymal transition and cell adhesion signal pathway.  |  Chen, W., et al. 2024. J Cancer Res Clin Oncol. 150: 398. PMID: 39180583
10. Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis.  |  Chan, XY., et al. 2024. Cell Mol Biol Lett. 29: 136. PMID: 39511483

The preferred Integrin β5/ITGB5 antibody is Integrin β5/ITGB5 Antibody (F-5): sc-398214.