Integrin β1/ITGB1 Antibody (MEM-101A): sc-51649
- Integrin β1/ITGB1 Antibody (MEM-101A) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against Burkitt's lymphoma human cell line Raji
- recommended for detection of Integrin β1 of human origin by WB (non-reducing), IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Integrin β1/ITGB1 (A-4): sc-374429 for Integrin β1/ITGB1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β1/ITGB1 Antibody (MEM-101A). This work is in progress.
QUICK LINKS
SEE ALSO...
Integrin β1 Antibody (MEM-101A) is a mouse monoclonal IgG1 antibody that detects Integrin β1 in human samples through western blotting (WB) under non-reducing conditions, immunoprecipitation (IP), and flow cytometry (FCM). Integrin β1 is a crucial component of the integrin family, consisting of heterodimers formed by noncovalently associated transmembrane α and β subunits. Anti-Integrin β1 antibody (MEM-101A) recognizes a protein that plays a vital role in mediating cell adhesion to the extracellular matrix and is involved in various cellular processes, including signaling pathways that regulate cell growth, differentiation, migration, and apoptosis. Integrin β1 forms more than 20 different receptor combinations when paired with various α subunits, enabling diverse interactions with ligands such as fibronectin, collagen, and vitronectin. These interactions maintain tissue integrity and facilitate communication between cells and their environment. Integrin β1 binding to soluble ligands and counterreceptors on adjacent cells, such as intracellular adhesion molecules (ICAMs), underscores Integrin β1′s significance in promoting cell aggregation and modulating immune responses. Anti-Integrin β1 antibody (MEM-101A) serves as an invaluable tool for researchers studying integrin roles in cellular dynamics and disease implications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin β1/ITGB1 Antibody (MEM-101A) References:
- Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. | Brockbank, EC., et al. 2005. Br J Cancer. 92: 102-12. PMID: 15597106
- SHARPIN is an endogenous inhibitor of β1-integrin activation. | Rantala, JK., et al. 2011. Nat Cell Biol. 13: 1315-24. PMID: 21947080
- The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma. | Wang, D., et al. 2012. Clin Cancer Res. 18: 4589-99. PMID: 22829201
- Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase. | Simpson, MA., et al. 2015. J Biol Chem. 290: 8360-72. PMID: 25694433
- Evaluation of β1-integrin expression on chondrogenically differentiating human adipose-derived stem cells using atomic force microscopy. | Quisenberry, CR., et al. 2016. Biointerphases. 11: 021005. PMID: 27106564
- Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. | Stritt, S., et al. 2018. Blood Adv. 2: 1040-1045. PMID: 29739775
- Circ_0085495 knockdown reduces adriamycin resistance in breast cancer through miR-873-5p/integrin β1 axis. | Xie, H. and Zheng, R. 2022. Anticancer Drugs. 33: e166-e177. PMID: 34387598
- Therapy-Naive and Radioresistant 3-Dimensional Pancreatic Cancer Cell Cultures Are Effectively Radiosensitized by β1 Integrin Targeting. | Görte, J., et al. 2022. Int J Radiat Oncol Biol Phys. 112: 487-498. PMID: 34481933
- Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice. | Mimouni, NEH., et al. 2022. Int J Mol Sci. 23: PMID: 36430291
- StarD7 deficiency hinders cell motility through p-ERK1/2/Cx43 reduction. | Cruz Del Puerto, M., et al. 2022. PLoS One. 17: e0279912. PMID: 36584213
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β1/ITGB1 Antibody (MEM-101A) | sc-51649 | 100 µg/ml | $322.00 | |||
Integrin β1/ITGB1 Antibody (MEM-101A) FITC | sc-51649 FITC | 100 tests in 2 ml | $336.00 | |||
Integrin β1/ITGB1 Antibody (MEM-101A) PE | sc-51649 PE | 100 tests in 2 ml | $349.00 |