Integrin β1/ITGB1 Antibody (4B7R): sc-9970

Integrin β1 Antibody (4B7R) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin β1 in mouse, rat, and human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin β1 antibody (4B7R) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrins, including Integrin β1, are crucial for cell adhesion and communication, as these heterodimers form through noncovalently associated transmembrane α and β subunits. The structural diversity of integrins, with 16 α and 8 β subunits, allows for the formation of over 20 different receptors, each capable of binding to specific ligands in the extracellular matrix, such as fibronectin, collagen, and vitronectin. This binding is essential for various cellular processes, including the activation of signaling pathways that regulate cell growth, differentiation, migration, and apoptosis. Notably, Integrin β1 plays a significant role in mediating cell-matrix interactions and is involved in the formation of focal adhesions, which are critical for maintaining tissue integrity and facilitating cellular responses to mechanical stimuli. Integrin β1′s ability to interact with other proteins, such as talin and vinculin, further underscores its importance in linking the extracellular environment to the cytoskeleton, thereby influencing cellular behavior and function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β1/ITGB1 Antibody (4B7R) has 127 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β1/ITGB1 Antibody (4B7R) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β1/ITGB1 Antibody (4B7R) Specifications

Alternate Product Name: CD29

Product Clone Name: 4B7R

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin β1

Epitope Species: human

Product Reactivity/Detection: Integrin β1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 127 citations in various scientific publications

Available Conjugates/Forms for Integrin β1/ITGB1 Antibody (4B7R): AC: Agarose, AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin β1/ITGB1 antibody is Integrin β1/ITGB1 Antibody (K-20): sc-18887.