Integrin α6b/ITGA6B/CD49f Antibody (6B4): sc-59971

Integrin αVIb Antibody (6B4) is a mouse monoclonal IgG1 antibody that detects Integrin αVIb of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Integrin αVIb antibody (6B4) is available in non-conjugated form. Integrins, including Integrin αVIb, are crucial for mediating cell adhesion and play a significant role in various cellular processes. The structure of Integrin αVIb consists of a unique combination of α and β subunits that form a heterodimer, allowing interaction with diverse ligands, such as components of the extracellular matrix and counterreceptors on adjacent cells. This structural versatility enables Integrin αVIb to participate in essential biological functions, including cell signaling, which influences cell growth, differentiation, migration, and apoptosis. The ability of Integrin αVIb to cluster and activate in response to ligand binding is vital for initiating integrin-mediated signaling pathways, making Integrin αVIb a key player in maintaining tissue integrity and facilitating cellular communication.

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Integrin α6b/ITGA6B/CD49f Antibody (6B4) References:

1. beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.  |  Levy, L., et al. 2000. Mol Biol Cell. 11: 453-66. PMID: 10679006
2. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
3. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.  |  Horton, MA., et al. 1985. Cancer Res. 45: 5663-9. PMID: 4053038
4. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
5. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
6. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
7. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α6b/ITGA6B/CD49f Antibody (6B4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α6b/ITGA6B/CD49f Antibody (6B4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α6b/ITGA6B/CD49f Antibody (6B4) Specifications

Alternate Product Name: Integrin alpha-6

Product Clone Name: 6B4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Integrin αVIb

Epitope Species: human

Product Reactivity/Detection: Integrin αVIb

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Integrin α6b/ITGA6B/CD49f Antibody (6B4): N/A