Integrin αL/ITGAL/CD11a Antibody (C-11): sc-373938

Integrin αL Antibody (C-11) is a mouse monoclonal IgM antibody that detects Integrin αL in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin αL, also called CD11a, is a crucial component of the immune system, primarily expressed on leukocytes, where Integrin αL plays a vital role in mediating cell adhesion and migration. Integrin αL is essential for the immune response, as Integrin αL facilitates the interaction between leukocytes and the endothelium during inflammation, allowing immune cells to exit the bloodstream and reach sites of infection or injury. The structure of Integrin αL, which consists of a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail, enables conformational changes necessary for activation and function. These structural features allow Integrin αL to bind to ligands, such as intercellular adhesion molecule-1 (ICAM-1), which is critical for leukocyte adhesion and transmigration. Anti-Integrin αL antibody (C-11) is an invaluable tool for researchers studying immune responses, cell signaling, and the mechanisms of inflammation, providing insights into the complex interactions that govern immune cell behavior.

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Integrin αL/ITGAL/CD11a Antibody (C-11) References:

1. Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.  |  Carreno, MP., et al. 2002. J Virol. 76: 32-40. PMID: 11739669
2. Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes.  |  Fagerholm, S., et al. 2002. Eur J Immunol. 32: 1670-8. PMID: 12115650
3. Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis.  |  Kawamura, A., et al. 2004. Circ J. 68: 6-10. PMID: 14695458
4. Regulation of expression of the leukocyte integrin CD11a (LFA-1) molecule during differentiation of HL-60 cells along the monocyte/macrophage pathway.  |  Back, AL., et al. 1992. J Immunol. 148: 710-4. PMID: 1730867
5. Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness.  |  Guttman-Yassky, E., et al. 2008. J Invest Dermatol. 128: 1182-91. PMID: 18239614
6. CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes.  |  Brenu, EW., et al. 2017. Immunol Cell Biol. 95: 803-813. PMID: 28611472
7. CD64, CD11a and CD18 leukocytes expression in children with SARS-CoV-2 multisystem inflammatory syndrome versus children with Kawasaki disease: Similar but not the same.  |  García-Salido, A., et al. 2021. Med Clin (Barc). 156: 89-91. PMID: 33160625
8. Intratracheal injection of endotoxin and cytokines. IX. Contribution of CD11a/ICAM-1 to neutrophil emigration.  |  Tang, WW., et al. 1995. Am J Physiol. 269: L653-9. PMID: 7491985
9. The expression of adhesion molecules, including CD11a and CD11b, on the human T lymphocyte surface membrane in patients with bronchial asthma.  |  Sumida, S. 1995. Kurume Med J. 42: 21-32. PMID: 7596088
10. Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.  |  Peter, K. and O'Toole, TE. 1995. J Exp Med. 181: 315-26. PMID: 7807011

The preferred Integrin αL/ITGAL/CD11a antibody is Integrin αL/ITGAL/CD11a Antibody (E-1): sc-374172.