Integrin α3b/ITGA3B Antibody (PB36): sc-59968
- Integrin α3b/ITGA3B Antibody (PB36) is a mouse monoclonal IgG1 Integrin α3b/ITGA3B antibody provided at 100 µg/ml
- raised against a 32 amino acid synthetic peptide corresponding to the cytoplastmic domain of Integrin αIIIb of human origin
- recommended for detection of the cytoplasmic domain of Integrin αIIIb and Integrin VIb of mouse, rat and human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α3b/ITGA3B Antibody (PB36). This work is in progress.
QUICK LINKS
SEE ALSO...
Integrin αIIIb/VIb Antibody (PB36) is a mouse monoclonal IgG1 antibody that detects Integrin αIIIb/VIb in mouse, rat, and human samples through western blotting (WB) and immunofluorescence (IF) applications. Anti-Integrin αIIIb/VIb antibody (PB36) is available as a non-conjugated format. Integrins, which are heterodimers formed by noncovalently associated transmembrane α and β subunits, play a crucial role in cell adhesion and signaling. The Integrin α3 chain, also referred to as very late activation antigen 3 (VLA-3), undergoes significant post-translational modifications, including cleavage in the extracellular domain, resulting in disulfide-linked light and heavy chains. This modification is essential as Integrin α3 effectively interacts with various extracellular matrix proteins, facilitating critical biological processes such as cell migration, differentiation, and survival. Integrin αIIIb/VIb binding to ligands like fibronectin and collagen underscores its importance in maintaining tissue integrity and mediating cellular responses to the extracellular environment. Anti-Integrin αIIIb/VIb antibody (PB36) enables researchers to gain valuable insights into the functional dynamics of integrins in various physiological and pathological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin α3b/ITGA3B Antibody (PB36) References:
- Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3. | Hantgan, RR., et al. 2003. J Biol Chem. 278: 3417-26. PMID: 12426312
- Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. | Goncalves, I., et al. 2003. J Biol Chem. 278: 34812-22. PMID: 12832405
- SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. | Maxwell, MJ., et al. 2004. J Biol Chem. 279: 32196-204. PMID: 15166241
- Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling. | Huang, CL., et al. 2004. J Biol Chem. 279: 42279-89. PMID: 15280374
- Integrins: versatility, modulation, and signaling in cell adhesion. | Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
- Integrins and signal transduction pathways: the road taken. | Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
- Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. | Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
- Epithelial integrins. | Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
- Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. | Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α3b/ITGA3B Antibody (PB36) | sc-59968 | 100 µg/ml | $316.00 |