Integrin α5/ITGA5/CD49e Antibody (P1D6): sc-13547

Integrin α5 Antibody (P1D6) is a mouse monoclonal IgG3 kappa light chain antibody that detects Integrin α5 of human and primate origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Integrin α5 antibody (P1D6) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Integrin α5 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Integrin α5 (P1D6) monoclonal antibody enables detection of this protein, which plays a significant role in mediating cell adhesion to the extracellular matrix, specifically binding to ligands such as fibronectin, collagen, and vitronectin. This interaction is vital for numerous cellular processes, including cell migration, proliferation, and survival, as Integrin α5 facilitates the transmission of signals from the extracellular environment to the cell interior. Integrin α5 (P1D6) antibody helps researchers study how this protein regulates cytoskeletal organization, which is essential for maintaining cell shape and enabling movement. Anti-Integrin α5 antibody (P1D6) supports research into both normal physiological processes and pathological conditions, such as cancer metastasis and tissue repair, by enabling investigation of this protein′s interactions with various ligands and signaling molecules.

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Integrin α5/ITGA5/CD49e Antibody (P1D6) References:

1. Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin.  |  Orecchia, A., et al. 2003. J Cell Sci. 116: 3479-89. PMID: 12865438
2. Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.  |  Mould, AP., et al. 2003. J Biol Chem. 278: 51622-9. PMID: 14532288
3. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
4. Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.  |  Kaabeche, K., et al. 2005. J Cell Sci. 118: 1223-32. PMID: 15728256
5. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.  |  Kuwada, SK., et al. 2005. J Biol Chem. 280: 19027-35. PMID: 15757908
6. Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.  |  Zhang, C., et al. 2020. Circ Res. 127: 1074-1090. PMID: 32673515
7. Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis.  |  Li, R., et al. 2023. Nat Commun. 14: 7555. PMID: 37985764
8. Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition.  |  Lu, L., et al. 2023. J Immunother Cancer. 11: PMID: 38040421
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α5/ITGA5/CD49e Antibody (P1D6) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α5/ITGA5/CD49e Antibody (P1D6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α5/ITGA5/CD49e Antibody (P1D6) Specifications

Alternate Product Name: Integrin α5

Product Clone Name: P1D6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids:

Epitope Target: Integrin α5

Epitope Species: human

Product Reactivity/Detection: Integrin α5

Species Reactivity/Detection: human, primate

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for Integrin α5/ITGA5/CD49e Antibody (P1D6): FITC: Fluoroscein, PE: Phycoerythrin