Integrin α1/ITGA1/CD49a Antibody (HM alpha 1): sc-59834
- Integrin α1/ITGA1/CD49a Antibody (HM alpha 1) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
- raised against Integrin α1 of mouse origin
- recommended for detection of Integrin α1 of mouse, rat and human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α1/ITGA1/CD49a Antibody (HM alpha 1). This work is in progress.
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Integrin α1 Antibody (HM alpha 1) is a hamster monoclonal IgG antibody that detects Integrin α1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Integrin α1 plays a crucial role in cell adhesion and signaling, functioning as a receptor that mediates interactions between cells and the extracellular matrix. Integrin α1 is primarily located on the cell surface, where anti-Integrin α1 antibody (HM alpha 1) can detect heterodimers formed with β subunits to create various integrin receptors. Integrin α1′s presence on the cell membrane is vital for maintaining tissue integrity and facilitating communication between cells and their environment. By binding to extracellular matrix components like collagen, Integrin α1 not only supports cell attachment but also initiates intracellular signaling pathways that influence cell behavior, including migration, proliferation, and survival. Integrin α1′s ability to interact with specific ligands underscores its importance in physiological processes such as wound healing and immune responses, making Integrin α1 a significant target for research in developmental biology and cancer studies. Integrin α1 monoclonal antibody (HM alpha 1) is an essential tool for researchers aiming to explore the multifaceted roles of integrins in cellular dynamics and disease mechanisms.
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Integrin α1/ITGA1/CD49a Antibody (HM alpha 1) References:
- Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. | Eble, JA., et al. 2006. J Biol Chem. 281: 25745-56. PMID: 16754661
- Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. | Shi, M., et al. 2012. J Biol Chem. 287: 35139-35152. PMID: 22888006
- Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-α1. | Kim, D., et al. 2013. Cell Signal. 25: 2878-87. PMID: 24018042
- Integrin α1 subunit is up-regulated in colorectal cancer. | Boudjadi, S., et al. 2013. Biomark Res. 1: 16. PMID: 24252313
- Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis. | Mickiewicz, B., et al. 2016. J Proteome Res. 15: 815-25. PMID: 26784366
- Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains. | Brown, KL., et al. 2018. Sci Rep. 8: 2916. PMID: 29440721
- Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer. | Li, H., et al. 2020. Int J Biol Sci. 16: 815-826. PMID: 32071551
- Ramipril therapy in integrin α1-null, autosomal recessive Alport mice triples lifespan: mechanistic clues from RNA-seq analysis. | Madison, J., et al. 2024. J Pathol. 262: 296-309. PMID: 38129319
- Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease. | Grenier, C., et al. 2024. bioRxiv.. PMID: 39484448
- Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation. | Paranitharan, N., et al. 2025. Biochem Biophys Res Commun. 742: 151151. PMID: 39657349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α1/ITGA1/CD49a Antibody (HM alpha 1) | sc-59834 | 200 µg/ml | $322.00 |