INSR/Insulin Receptor β Antibody (29B4): sc-09
- INSR/Insulin Receptor β Antibody (29B4) is a mouse monoclonal IgG1, cited in 60 publications, provided at 100 µg/ml
- epitope mapping to an intracellular region of the 95 kDa β chain of the human insulin receptor
- recommended for detection of insulin Rβ chain of mouse, rat and human origin by WB, IP and KA; not recommended for WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for INSR/Insulin Receptor β Antibody (29B4). This work is in progress.
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Insulin Rβ Antibody (29B4) is a mouse monoclonal IgG1 antibody engineered to recognize an intracellular epitope on the 95 kDa β chain of the human insulin receptor. The insulin receptor is a vital transmembrane protein complex located on the cell surface, where it plays a crucial role in regulating glucose uptake and metabolism by binding insulin and triggering essential signaling pathways. The β subunit of the insulin receptor resides within the cytoplasm, where its intrinsic tyrosine kinase activity is essential for phosphorylating intracellular substrates and propagating the insulin signal, thereby facilitating processes such as glucose transport and glycogen synthesis. Understanding the localization and function of the β subunit is pivotal for elucidating the mechanisms of insulin action and the development of insulin resistance in metabolic disorders. Insulin Rβ (29B4) monoclonal antibody is recommended for applications including immunoprecipitation (IP) and kinase assays (KA) across multiple species, including mouse, rat, and human, making it a versatile tool for research in various model systems. Insulin Rβ (29B4) antibody supports studies into insulin signaling pathways, offering insights into the molecular underpinnings of conditions such as type 1 and type 2 diabetes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INSR/Insulin Receptor β Antibody (29B4) | sc-09 | 100 µg/ml | $333.00 |