Date published: 2025-9-18

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Inosine 5′-monophosphate (CAS 131-99-7)

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Alternate Names:
I-5′-P; Inosinic Acid; IMP
Application:
Inosine 5′-monophosphate is an IMPDH substrate
CAS Number:
131-99-7
Purity:
≥98%
Molecular Weight:
348.21
Molecular Formula:
C10H13N4O8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Inosine 5′-monophosphate (IMP), also known as inosinic acid, plays a role in purine metabolism and is vital for the generation of adenosine triphosphate (ATP), the primary source of energy in the body. Inosinic acid is a nucleotide, a compound composed of a nitrogenous base, a ribose sugar, and a phosphate group. Within the purine metabolism pathway, inosinic acid serves as a significant intermediate. It is synthesized through the enzymatic action of adenylosuccinate synthetase, which converts AMP and aspartic acid into inosinic acid and succinic acid. Subsequently, inosinic acid undergoes further transformation into adenosine monophosphate (AMP) with the assistance of adenylosuccinate lyase. This process is indispensable for the synthesis of ATP, the primary energy currency within the body.


Inosine 5′-monophosphate (CAS 131-99-7) References

  1. Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate.  |  Nair, V. and Kamboj, RC. 2003. Bioorg Med Chem Lett. 13: 645-7. PMID: 12639549
  2. Protection of mice against X-ray injuries by the post-irradiation administration of inosine-5'-monophosphate.  |  Asadullina, NR., et al. 2012. J Radiat Res. 53: 211-6. PMID: 22510593
  3. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.  |  Makowska-Grzyska, M., et al. 2012. Biochemistry. 51: 6148-63. PMID: 22788966
  4. [The basic functions of inosine 5'-monophosphate dehydrogenase and its application in drug discovery].  |  Zhang, YW., et al. 2014. Yao Xue Xue Bao. 49: 285-92. PMID: 24961097
  5. Inosine-5'-monophosphate is a candidate agent to resolve rigor mortis of skeletal muscle.  |  Matsuishi, M., et al. 2016. Anim Sci J. 87: 1407-1412. PMID: 26875616
  6. Thermal behavior of inosine 5'-monophosphate in acidic form and as alkali and alkaline earth salts.  |  de Jesus, JHF., et al. 2018. Food Chem. 258: 199-205. PMID: 29655723
  7. Inosine 5'-Monophosphate to Raise Serum Uric Acid Level in Multiple System Atrophy (IMPROVE-MSA study).  |  Jung Lee, J., et al. 2021. Clin Pharmacol Ther. 109: 1274-1281. PMID: 33064299
  8. The Application of In Silico Methods on Umami Taste Receptor.  |  Spaggiari, G., et al. 2022. Handb Exp Pharmacol. 275: 137-154. PMID: 34247277
  9. Dietary supplementation with inosine-5'-monophosphate improves the functional, energetic, and antioxidant status of liver and muscle growth in pigs.  |  Bonagurio, LP., et al. 2022. Sci Rep. 12: 350. PMID: 35013384
  10. The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases.  |  Buey, RM., et al. 2022. Protein Sci. 31: e4399. PMID: 36040265
  11. The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression.  |  Luo, XM., et al. 2022. Commun Biol. 5: 1088. PMID: 36224248
  12. Taste Characteristics of Various Amino Acid Derivatives.  |  Tanase, R., et al. 2022. J Nutr Sci Vitaminol (Tokyo). 68: 475-480. PMID: 36310083
  13. Responses of neurons in the primate taste cortex to the glutamate ion and to inosine 5'-monophosphate.  |  Rolls, ET., et al. 1996. Physiol Behav. 59: 991-1000. PMID: 8778897

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Inosine 5′-monophosphate, 1 g

sc-215179
1 g
$195.00