Inhibin β-B Antibody (B-9): sc-390959

Inhibin β-B Antibody (B-9) is a mouse monoclonal IgG3 antibody that detects Inhibin β-B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Inhibin β-B plays a crucial role in regulating reproductive hormones, specifically by inhibiting follicle-stimulating hormone (FSH) secretion from the pituitary gland, which is essential for normal reproductive function and fertility. This regulation helps maintain the hormone balance necessary for proper gonadal function and germ cell development. Inhibin β-B is predominantly expressed in liver and gonadal tissues, where Inhibin β-B presence is critical for modulating reproductive processes. The protein′s structure, consisting of a dimer formed by α and β-B subunits, determines biological activity and interaction with other proteins in the TGFβ superfamily. Understanding Inhibin β-B structure and function provides insights into various physiological processes and potential implications in reproductive health and disorders. Anti-Inhibin β-B antibody (B-9) serves as an invaluable tool for scientists studying these complex regulatory mechanisms.

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Inhibin β-B Antibody (B-9) References:

1. Pachytene spermatocytes in co-culture inhibit rat Sertoli cell synthesis of inhibin beta B-subunit and inhibin B but not the inhibin alpha-subunit.  |  Clifton, RJ., et al. 2002. J Endocrinol. 172: 565-74. PMID: 11874705
2. Activation of the bone morphogenetic protein signaling pathway induces inhibin beta(B)-subunit mRNA and secreted inhibin B levels in cultured human granulosa-luteal cells.  |  Jaatinen, R., et al. 2002. J Clin Endocrinol Metab. 87: 1254-61. PMID: 11889196
3. Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli cells: consequences for the production of bioactive and immunoreactive inhibin.  |  Klaij, IA., et al. 1992. Mol Cell Endocrinol. 85: 237-46. PMID: 1634019
4. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease.  |  Sjöholm, K., et al. 2006. Biochem Biophys Res Commun. 344: 1308-14. PMID: 16650820
5. BamHI RFLP of the inhibin beta B (INHBB) chain gene on chromosome 2.  |  Chenevix-Trench, G., et al. 1990. Nucleic Acids Res. 18: 7469. PMID: 1979678
6. Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.  |  Johnson, MP., et al. 2012. PLoS One. 7: e33666. PMID: 22432041
7. OP004. A SNP associated with susceptibility to preeclampsia near the inhibin, beta B gene, is also associated with cardiovascular disease risk traits.  |  Løset, M., et al. 2013. Pregnancy Hypertens. 3: 63. PMID: 26105849
8. Single nucleotide polymorphisms near the inhibin beta B gene on 2q14 are associated with pre-eclampsia in Han Chinese women.  |  Wang, Q., et al. 2015. Eur J Obstet Gynecol Reprod Biol. 193: 127-31. PMID: 26313529
9. Localization of the inhibin beta B gene on mouse chromosome 1.  |  Lafuse, WP. and Zwilling, BS. 1993. Mamm Genome. 4: 399-400. PMID: 8358176
10. Occurrence of immunoreactive activin/inhibin beta(B) in gonadotrophs, thyrotrophs, and somatotrophs of the Xenopus pituitary.  |  Uchiyama, H., et al. 1996. Gen Comp Endocrinol. 102: 1-10. PMID: 8860302

The preferred Inhibin β-A antibody is Inhibin β-A Antibody (E-1): sc-166503.