ING3 Antibody (162.1): sc-101245

ING3 Antibody (162.1) is a mouse monoclonal IgG2b kappa light chain antibody that detects ING3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ING3 antibody (162.1) is available as the non-conjugated format. ING3 is a crucial nuclear tumor-suppressor that plays a significant role in regulating cellular responses to stress, particularly in UV-induced damage. ING3 activates apoptosis through a FAS-mediated pathway, which is vital for eliminating damaged cells and preventing cancer development. ING3 is involved in p53-mediated transcription and apoptosis, functioning as a component of the NuA4 complex histone acetyltransferase complex. This interaction modifies chromatin structure and facilitates transcription of genes involved in cell cycle regulation and apoptosis. Overexpression of ING3 has been linked to increased cleavage of apoptosis-related caspases and BID, although this occurs through a mechanism that doesn′t involve mitochondrial protein upregulation. Defects in ING3 can lead to impaired UV-induced apoptosis, which significantly influences the prognosis of melanomas and head and neck cancers, highlighting ING3′s importance in cancer biology and therapeutic strategies.

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ING3 Antibody (162.1) References:

1. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers.  |  Gunduz, M., et al. 2002. Oncogene. 21: 4462-70. PMID: 12080476
2. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis.  |  Nagashima, M., et al. 2003. Oncogene. 22: 343-50. PMID: 12545155
3. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.  |  Doyon, Y., et al. 2004. Mol Cell Biol. 24: 1884-96. PMID: 14966270
4. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.  |  Gunduz, M., et al. 2005. Gene. 356: 109-17. PMID: 15935570
5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.  |  Doyon, Y., et al. 2006. Mol Cell. 21: 51-64. PMID: 16387653
6. ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells.  |  Wang, Y. and Li, G. 2006. J Biol Chem. 281: 11887-93. PMID: 16520380
7. Prognostic significance of nuclear ING3 expression in human cutaneous melanoma.  |  Wang, Y., et al. 2007. Clin Cancer Res. 13: 4111-6. PMID: 17634537
8. Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer.  |  Gunduz, M., et al. 2008. Cancer Sci. 99: 531-8. PMID: 18081876

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ING3 Antibody (162.1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ING3 Antibody (162.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ING3 Antibody (162.1) Specifications

Alternate Product Name: ING3

Product Clone Name: 162.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-93

Epitope Target: ING3

Epitope Species: human

Product Reactivity/Detection: ING3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ING3 Antibody (162.1): N/A