Influenza A Virus Hemagglutinin Antibody (18D5): sc-66144

Influenza A Virus Hemagglutinin Antibody (18D5) is a mouse monoclonal IgG2a antibody that specifically recognizes Influenza A Virus Hemagglutinin through enzyme-linked immunosorbent assay (ELISA). Influenza A Virus Hemagglutinin is a critical glycoprotein located on the viral surface, playing a vital role in host cell infection. Anti-Influenza A Virus Hemagglutinin antibody (18D5) binds to a protein that facilitates initial viral attachment to host cells through sialic acid residues on epithelial cell surfaces, essential for viral entry and replication. The structure of hemagglutinin comprises two subunits, HA1 and HA2, with HA1 responsible for receptor binding and HA2 mediating membrane fusion. Understanding hemagglutinin′s structure and function remains crucial for developing effective vaccines and antiviral therapies, as this surface protein serves as a primary target for neutralizing antibodies. Influenza A Virus Hemagglutinin monoclonal antibody (18D5) serves as an invaluable tool for studying influenza virus infection mechanisms and immune responses.

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Influenza A Virus Hemagglutinin Antibody (18D5) References:

1. Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases.  |  Zhirnov, OP., et al. 2002. J Virol. 76: 8682-9. PMID: 12163588
2. Repository of Eurasian influenza A virus hemagglutinin and neuraminidase reverse genetics vectors and recombinant viruses.  |  Keawcharoen, J., et al. 2010. Vaccine. 28: 5803-9. PMID: 20600474
3. Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.  |  Das, SR., et al. 2013. Cell Host Microbe. 13: 314-23. PMID: 23498956
4. Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity.  |  Magadán, JG., et al. 2013. J Virol. 87: 9742-53. PMID: 23824811
5. Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection.  |  To, KK., et al. 2015. Arch Virol. 160: 777-86. PMID: 25616843
6. Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4.  |  Song, H., et al. 2017. Cell Rep. 20: 1201-1214. PMID: 28768203
7. TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.  |  Zmora, P., et al. 2018. J Biol Chem. 293: 13863-13873. PMID: 29976755
8. Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.  |  Ilyushina, NA., et al. 2019. Virol J. 16: 149. PMID: 31783761
9. Synergistic Effect between 3'-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference.  |  Xiao, Y., et al. 2021. J Virol. 95: e0087821. PMID: 34190596
10. Postreassortment changes in influenza A virus hemagglutinin restoring HA-NA functional match.  |  Kaverin, NV., et al. 1998. Virology. 244: 315-21. PMID: 9601502

The preferred Influenza A Virus Hemagglutinin antibody is Influenza A Virus Hemagglutinin Antibody (C102): sc-52025.