Influenza A m2 Antibody (14C2): sc-32238

Influenza A m2 Antibody (14C2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Influenza A m2 protein by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Influenza A m2 antibody (14C2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Influenza A m2 protein plays a crucial role in the viral life cycle, functioning as a proton channel that facilitates the acidification of the viral interior, which is essential for the uncoating process during infection. Influenza A m2 protein′s ability to form a highly selective, pH-regulated channel allows protons to enter the virus, leading to a decrease in pH that disrupts the interaction between the matrix protein m1 and the ribonucleoprotein complex. This disruption is vital for the release of viral RNA into the host cell, ultimately enabling viral replication. Understanding Influenza A m2 protein function is important for developing antiviral strategies, as this target presents opportunities for therapeutic intervention in influenza infections.

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Influenza A m2 Antibody (14C2) References:

1. Experimentally based orientational refinement of membrane protein models: A structure for the Influenza A M2 H+ channel.  |  Kukol, A., et al. 1999. J Mol Biol. 286: 951-62. PMID: 10024461
2. Mechanism for proton conduction of the M(2) ion channel of influenza A virus.  |  Mould, JA., et al. 2000. J Biol Chem. 275: 8592-9. PMID: 10722698
3. Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 protein.  |  Ali, A., et al. 2000. J Virol. 74: 8709-19. PMID: 10954572
4. Update on influenza and other viral pneumonias.  |  Fleming, DM. and Zambon, M. 2001. Curr Opin Infect Dis. 14: 199-204. PMID: 11979133
5. Influenza A M2 protein conformation depends on choice of model membrane.  |  Saotome, K., et al. 2015. Biopolymers. 104: 405-11. PMID: 25652904
6. Mechanisms of Action of Novel Influenza A/M2 Viroporin Inhibitors Derived from Hexamethylene Amiloride.  |  Jalily, PH., et al. 2016. Mol Pharmacol. 90: 80-95. PMID: 27193582
7. Divalent copper complexes as influenza A M2 inhibitors.  |  Gordon, NA., et al. 2017. Antiviral Res. 147: 100-106. PMID: 29032206
8. The distal cytoplasmic tail of the influenza A M2 protein dynamically extends from the membrane.  |  Kim, G., et al. 2019. Biochim Biophys Acta Biomembr. 1861: 1421-1427. PMID: 31153909
9. Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels.  |  Tzitzoglaki, C., et al. 2020. ACS Chem Biol. 15: 2331-2337. PMID: 32786258
10. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics.  |  Watkins, LC., et al. 2020. J Am Chem Soc. 142: 17425-17433. PMID: 32933245
11. Influenza A M2 recruits M1 to the plasma membrane: A fluorescence fluctuation microscopy study.  |  Petrich, A., et al. 2021. Biophys J. 120: 5478-5490. PMID: 34808098
12. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.  |  Pinto, LH., et al. 1997. Proc Natl Acad Sci U S A. 94: 11301-6. PMID: 9326604

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Influenza A m2 Antibody (14C2) has 49 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Influenza A m2 Antibody (14C2) Specifications

Alternate Product Name: Influenza A Matrix-2 (M2) protein

Product Clone Name: 14C2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 50-68

Epitope Target: Influenza A m2

Epitope Species: Influenza A virus

Product Reactivity/Detection: Influenza A m2

Species Reactivity/Detection: Influenza A protein m2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 49 citations in various scientific publications

Available Conjugates/Forms for Influenza A m2 Antibody (14C2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin