You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
INDY is a stem cell reagent that reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. INDY impairs the self-renewal capacity of subventricular zone neural stem cells. INDY is also a Dyrk1A/B inhibitor, IC50 values are 0.23 and 0.24 μM, for Dyrk1B and Dyrk1A, respectively.
1. Ogawa, Yasushi., et al., 2010. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature communications. 1(): 86. PMID: 20981014
2. Pozo, Natividad., et al., 2013. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. The Journal of clinical investigation. 123(6): 2475-87. PMID: 23635774
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.