Date published: 2025-9-11

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Indoxyl sulfate potassium salt (CAS 2642-37-7)

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Alternate Names:
Potassium 3-indoxyl sulfate
Application:
Indoxyl sulfate potassium salt is an agonist for the human aryl hydrocarbon receptor (AHR)
CAS Number:
2642-37-7
Purity:
≥97%
Molecular Weight:
251.30
Molecular Formula:
C8H6NO4S•K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Indoxyl sulfate potassium salt is a prominent compound utilized extensively in various research applications, particularly in studies related to environmental biology and biochemistry. This salt form of indoxyl sulfate enhances solubility in aqueous solutions, facilitating its use in experimental setups where precise solubility and dispersal are required. In research, it is primarily employed as a model compound to study the transport mechanisms of organic anions in cellular systems. The presence of the potassium ion is critical as it affects the ionic strength and electrical conductivity of solutions, which are essential parameters in studies involving membrane transport and enzyme kinetics. Indoxyl sulfate potassium salt is also pivotal in ecological studies, especially in understanding the metabolic pathways of aromatic compounds in soil and water environments, where it serves as a tracer or an indicator of biochemical activity. Through its interactions and transformations, it provides insights into the microbial degradation processes and the environmental fate of similar organic compounds.


Indoxyl sulfate potassium salt (CAS 2642-37-7) References

  1. Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC.  |  Carlson, M. and Thompson, RD. 2001. J AOAC Int. 84: 782-8. PMID: 11417643
  2. Uremic toxicity of indoxyl sulfate.  |  Niwa, T. 2010. Nagoya J Med Sci. 72: 1-11. PMID: 20229698
  3. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists.  |  Zgoda-Pols, JR., et al. 2011. Toxicol Appl Pharmacol. 255: 48-56. PMID: 21640743
  4. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.  |  Shimizu, H., et al. 2013. Am J Nephrol. 37: 97-103. PMID: 23363842
  5. Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3.  |  Akiyama, Y., et al. 2013. PLoS One. 8: e66518. PMID: 23874392
  6. Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate.  |  Ahmed, MS., et al. 2013. BMC Nephrol. 14: 244. PMID: 24188099
  7. Binding affinity and capacity for the uremic toxin indoxyl sulfate.  |  Devine, E., et al. 2014. Toxins (Basel). 6: 416-29. PMID: 24469432
  8. Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation.  |  Ito, S., et al. 2016. J Atheroscler Thromb. 23: 960-75. PMID: 26860885
  9. LC-MS/MS method for simultaneous determination of serum p-cresyl sulfate and indoxyl sulfate in patients undergoing peritoneal dialysis.  |  Shu, C., et al. 2016. Biomed Chromatogr. 30: 1782-1788. PMID: 27129599
  10. Removal of indoxyl sulfate by water-soluble poly-cyclodextrins in dialysis.  |  Li, J., et al. 2018. Colloids Surf B Biointerfaces. 164: 406-413. PMID: 29428659
  11. Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.  |  Takada, T., et al. 2018. Sci Rep. 8: 11147. PMID: 30042379
  12. The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.  |  Liao, YL., et al. 2019. J Vet Intern Med. 33: 686-693. PMID: 30779214
  13. Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study).  |  Di Iorio, BR., et al. 2019. J Clin Med. 8: PMID: 31510015
  14. A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells.  |  Ahmed, S., et al. 2022. Biomed Chromatogr. 36: e5307. PMID: 34978088
  15. Quantification of Tryptophan, Indole, and Indoxyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry.  |  Baird, S., et al. 2022. Methods Mol Biol. 2546: 493-500. PMID: 36127616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indoxyl sulfate potassium salt, 250 mg

sc-255218
250 mg
$84.00

Indoxyl sulfate potassium salt, 1 g

sc-255218A
1 g
$186.00

Indoxyl sulfate potassium salt, 5 g

sc-255218B
5 g
$810.00

Indoxyl sulfate potassium salt, 10 g

sc-255218C
10 g
$1595.00