Date published: 2026-5-19

1-800-457-3801

SCBT Portrait Logo
Seach Input

Indoramin hydrochloride (CAS 38821-52-2)

0.0(0)
Write a reviewAsk a question

Alternate Names:
N-[1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl] benzamide hydrochloride
Application:
Indoramin hydrochloride is an a-adrenoceptor antagonist
CAS Number:
38821-52-2
Purity:
≥98%
Molecular Weight:
383.91
Molecular Formula:
C22H26ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Indoramin hydrochloride is an alpha-1 adrenergic receptor antagonist. It acts by competitively inhibiting the binding of norepinephrine to alpha-1 adrenergic receptors, leading to vasodilation and a decrease in peripheral vascular resistance. Indoramin Hydrochloride′s mechanism of action involves blocking the sympathetic nervous system′s stimulation of smooth muscle cells in blood vessels, resulting in relaxation and widening of the vessels. This mechanism ultimately leads to a reduction in blood pressure. At the molecular level, indoramin hydrochloride interferes with the signaling pathway that mediates vasoconstriction, thereby modulating the physiological response to sympathetic stimulation. Indoramin Hydrochloride′s function in experimental applications involves its ability to target and block alpha-1 adrenergic receptors, leading to the desired physiological effects related to blood pressure regulation.


Indoramin hydrochloride (CAS 38821-52-2) References

  1. Effects of indoramin in rat vas deferens and aorta: concomitant alpha1-adrenoceptor and neuronal uptake blockade.  |  Pupo, AS., et al. 1999. Br J Pharmacol. 127: 1832-6. PMID: 10482913
  2. A proconvulsant action of selective alpha 2-adrenoceptor antagonists.  |  Fletcher, A. and Forster, EA. 1988. Eur J Pharmacol. 151: 27-34. PMID: 2901362
  3. Pharmacokinetics and systemic availability of the antihypertensive agent indoramin and its metabolite 6-hydroxyindoramin in healthy subjects.  |  Pierce, DM., et al. 1987. Eur J Clin Pharmacol. 32: 619-23. PMID: 3653231
  4. Liquid chromatographic assay using electrochemical detection for the quantitation of indoramin in human plasma.  |  Leelavathi, DE., et al. 1986. J Pharm Sci. 75: 421-3. PMID: 3723366
  5. Further observations on the experimental antidysrhythmic activity of indoramin hydrochloride.  |  Rashid, S. and Alps, BJ. 1973. J Pharm Pharmacol. 25: 700-4. PMID: 4148504
  6. A comparison of the cardiovascular actions of indoramin, propranolol, lignocaine, and quinidine.  |  Alps, BJ., et al. 1972. Cardiovasc Res. 6: 226-34. PMID: 4338471
  7. The reversal of experimental cardiac arrhythmias by indoramin (Wy 21901).  |  Alps, BJ., et al. 1971. J Pharm Pharmacol. 23: 678-86. PMID: 4398246
  8. Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901).  |  Alps, BJ., et al. 1972. Br J Pharmacol. 44: 52-62. PMID: 4401308
  9. Myocardial effects of indoramin hydrochloride, a new hypotensive agent.  |  Coltart, DJ., et al. 1971. Br J Pharmacol. 42: 664P-665P. PMID: 5116056
  10. Interaction of selective alpha-adrenoceptor agonists and antagonists with human and rabbit blood platelets.  |  Grant, JA. and Scrutton, MC. 1980. Br J Pharmacol. 71: 121-34. PMID: 6110451
  11. Effect of indoramin on human sperm motility.  |  Verma, RB., et al. 1983. Br J Clin Pharmacol. 15: 127-8. PMID: 6849738
  12. Central sympathetic reactivity inhibited by indoramin.  |  Davison, M. and Koss, M. 1980. Eur J Pharmacol. 68: 193-6. PMID: 7202486
  13. Cutaneous arterial and venous alpha receptor blocking activity following intraduodenal indoramin to dogs  |  Greenberg, S., & Touhey, B. 1990. Drug development research. 19(1): 63-77.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indoramin hydrochloride, 10 mg

sc-252906
10 mg
$109.00