Molecular structure of Indomethacin heptyl ester
Indomethacin heptyl ester
Application:
Indomethacin heptyl ester is a selective Cox-2 inhibitor that reduces expression and activity of MDR-1
Molecular Weight:
456.0
Molecular Formula:
C26H30ClNO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Indomethacin heptyl ester (indo HE) is a highly selective Cox-2 (cyclooxygenase-2) inhibitor that prevents arachidonic acid (sc-200770) metabolism into prostaglandins. Indomethacin heptyl ester has been shown to also reduce the expression and activity of P-glycoprotein (MDR-1) in murine experiments. MDR-1 is an ABC transporter that mediates barrier transport through cell membranes.
Indomethacin heptyl ester References
- Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study. | Wang, M., et al. 2005. J Neurooncol. 72: 1-9. PMID: 15803368
- Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line. | Zrieki, A., et al. 2008. Pharm Res. 25: 1991-2001. PMID: 18581209
- Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | Suh, HN., et al. 2008. Am J Physiol Cell Physiol. 295: C1518-27. PMID: 18842827
- Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. | Zibell, G., et al. 2009. Neuropharmacology. 56: 849-55. PMID: 19371577
- The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death. | Wellmann, S., et al. 2010. Pediatr Res. 67: 35-41. PMID: 19770690
- Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo. | Zrieki, A., et al. 2010. Eur J Pharmacol. 636: 189-97. PMID: 20361960
- COX-2 inhibition and inhibition of cytosolic phospholipase A2 increase CD36 expression and foam cell formation in THP-1 cells. | Anwar, K., et al. 2011. Lipids. 46: 131-42. PMID: 21181286
- Effects of Nonsteroidal Anti-inflammatory Drugs on the Self-renewal Capacity of Blast Progenitors in Hematological Malignancies. | Yi, Z., et al. 2017. Anticancer Res. 37: 2315-2322. PMID: 28476797
- Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines. | Kawaguchi-Ihara, N., et al. 2019. Anticancer Res. 39: 87-98. PMID: 30591444
- Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling. | Lin, CC., et al. 2019. Cancer Lett. 457: 86-97. PMID: 31100409
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indomethacin heptyl ester, 1 mg | sc-221758 | 1 mg | $24.00 | |||
Indomethacin heptyl ester, 5 mg | sc-221758A | 5 mg | $110.00 |